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Multi-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer�s Disease

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dc.contributor.authorBhatia, Rohit
dc.contributor.authorChakrabarti, Sankha S.
dc.contributor.authorKaur, Upinder
dc.contributor.authorParashar, Gaurav
dc.contributor.authorBanerjee, Anindita
dc.contributor.authorRawal, Ravindra K.
dc.date.accessioned2025-01-30T05:56:21Z
dc.date.available2025-01-30T05:56:21Z
dc.date.issued2021
dc.description.abstractAlzheimer�s disease (AZD) is an age-associated neurodegenerative disorder and is one of the common health issues around the globe. It is characterized by memory loss and a decline in other cognitive domains, including executive function. The progression of AZD is associated with complex events, and the exact pathogenesis is still unrevealed. Various mechanisms which are thought to be associated with the initiation of AZD include a decreased concentration of acetylcholine (ACh), deposition of amyloid-? (A?) peptide, dyshomeostasis of redox metal ions, and prolonged oxidative stress. Due to the simultaneous progression of diverse pathogenetic pathways, no ideal therapeutic agent has been developed to date. The drugs which are available against AZD provide only symptomatic benefits and do not have disease-modifying activity. Therefore, in search of ideal therapeutic candidates, the concept of molecular hybrids has been under keen investigation for the past few years. Hybrid molecules are able to inhibit or activate or modify the physiology of more than one target simultaneously. Coumarin scaffold have shown the excellent potential of ACh esterase inhibition, MAO-B inhibition, and anti-A? aggregation. In the present review, we have focused on different reported coumarin hybrids as multi-target-directed agents against AZD. These include hybrids of coumarin with carbazole, benzofuran, dithiocarbamate, quinoline, pargyline, tacrine, N-benzyl pyridinium, donepezil, purine, piperidine, morpholine, aminophenol, benzylamino, halophenylalkylamidic, thiazole, thiourea, hydroxypyridinone, triazole, piperazine, chalcone, etc. Along with the therapeutic potentials of these hybrids, important clinical investigations and the structure-activity relationship have also been discussed in this compilation. � 2021 Bentham Science Publishers.
dc.identifier.doihttps://doi.org/10.2174/1567205018666211208140551
dc.identifier.issn15672050
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/24556
dc.publisherBentham Science Publishers
dc.subjectAChE
dc.subjectAlzheimer�s disease
dc.subjectCoumarin hybrids
dc.subjectDonepezil
dc.subjectMAO-B
dc.subjectTacrine
dc.titleMulti-Target Directed Ligands (MTDLs): Promising Coumarin Hybrids for Alzheimer�s Disease
dc.typeReview
dspace.entity.typePublication
journal.titleCurrent Alzheimer Research
journalvolume.identifier.volume18

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2021