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Allethrin-induced genotoxicity and oxidative stress in Swiss albino mice

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dc.contributor.authorSrivastava, Amit Kumar
dc.contributor.authorSrivastava, Pramod Kumar
dc.contributor.authorAl-Khedhairy, Abdulaziz A.
dc.contributor.authorMusarrat, Javed
dc.contributor.authorShukla, Yogeshwer
dc.date.accessioned2025-03-03T08:37:56Z
dc.date.available2025-03-03T08:37:56Z
dc.date.issued2012
dc.description.abstractAllethrin (C19H26O3) is non-cyano-containing pyrethroid insecticide that is used extensively for controlling flies and mosquitoes. Apart from its neurotoxic effects in non-target species, allethrin is reported to be mutagenic in bacterial systems. In this study, we observed oxidative damage-mediated genotoxicity caused by allethrin in Swiss albino mice. The genotoxic potential of allethrin was evaluated using chromosome aberrations (CAs) and a micronuclei (MN) induction assay as genetic end-points. The oral intubation of allethrin (25 and 50mg/kg b.wt.) significantly induces CAs and MN in mouse bone marrow cells. The DNA-damaging potential of allethrin was estimated in mouse liver using the DNA alkaline unwinding assay (DAUA) and by measuring the levels of 8-hydroxy-2'-deoxy-guanosine (8-OH-dG). Furthermore, a dose-dependent increase in reactive oxygen species (ROS) generation and lipid peroxidation (LPO), with a concurrent decrease in superoxide dismutase (SOD) and catalase, confirm its pro-oxidant potential. The DNA-damaging potential of allethrin was found to be mediated through the modulation of p53, p21, GADD45α and MDM-2. These results confirm the genotoxic and the pro-oxidant potential of allethrin in Swiss albino mice. © 2012.
dc.identifier.doihttps://doi.org/10.1016/j.mrgentox.2012.03.003
dc.identifier.issn13835718
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/79484
dc.publisherElsevier B.V.
dc.subjectAllethrin: Genotoxicity
dc.subjectChromosomal aberrations
dc.subjectMicronuclei
dc.subjectSwiss albino mice
dc.titleAllethrin-induced genotoxicity and oxidative stress in Swiss albino mice
dc.typeRetracted
dspace.entity.typePublication
journal.titleMutation Research - Genetic Toxicology and Environmental Mutagenesis
journalvolume.identifier.volume747

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