Publication:
Innate Immune Mechanism of Neutrophil Extracellular Trap Formation is Impaired in at-Risk Term Low Birth Weight Newborns

dc.contributor.authorDas, Doli
dc.contributor.authorSingh, Vikas V.
dc.contributor.authorChauhan, Sudhir K.
dc.contributor.authorRai, Richa
dc.contributor.authorKumar, Ashok
dc.contributor.authorJain, Madhu
dc.contributor.authorRai, Geeta
dc.date.accessioned2025-01-28T10:05:27Z
dc.date.available2025-01-28T10:05:27Z
dc.date.issued2023
dc.description.abstractLow birth weight (LBW) is a leading cause of newborn�s mortality however the underlying defects in cellular immunity and immune mechanisms leading to severe neonatal infections in term LBW (tLBW) newborns are not well understood. Neutrophil extracellular traps (NETs), or NETosis, is an innate immune defense mechanism of neutrophils involved in trapping and killing of microbes. The efficiency of NET formation in cord blood derived neutrophils of tLBW and normal birth weight (NBW) newborns in the presence of toll like receptor (TLR) agonist inductions was evaluated. The NET formation was observed to be substantially impaired in tLBW newborns along with NET proteins expression, extracellular deoxyribonucleic acid (DNA) release and reactive oxygen species generation. The placental tissues from tLBW newborns delivery also showed minimal NETosis. These findings suggest impaired NET formation to be an important factor underlying the deficient immune status of tLBW newborns making them susceptible to life- threatening infections. � 2023 Taylor & Francis Group, LLC.
dc.identifier.doihttps://doi.org/10.1080/08880018.2023.2218409
dc.identifier.issn8880018
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/23518
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.subjectlow birth weight
dc.subjectNETosis
dc.subjectNeutrophil extracellular trap
dc.subjectplacenta
dc.subjecttoll-like receptor
dc.titleInnate Immune Mechanism of Neutrophil Extracellular Trap Formation is Impaired in at-Risk Term Low Birth Weight Newborns
dc.typeArticle
dspace.entity.typePublication
journal.titlePediatric Hematology and Oncology
journalvolume.identifier.volume40

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