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Force-induced melting of DNA hairpin: Unfolding pathways and phase diagrams

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dc.contributor.authorRudra, Sumitra
dc.contributor.authorChauhan, Keerti
dc.contributor.authorSingh, Amit Raj
dc.contributor.authorKumar, Sanjay
dc.date.accessioned2025-01-28T09:47:51Z
dc.date.available2025-01-28T09:47:51Z
dc.date.issued2023
dc.description.abstractUsing the exact enumeration technique, we have studied the force-induced melting of a DNA hairpin on the face centered cubic lattice for two different sequences which differ in terms of loop closing base pairs. The melting profiles obtained from the exact enumeration technique is consistent with the Gaussian network model and Langevin dynamics simulations. Probability distribution analysis based on the exact density of states revealed the microscopic details of the opening of the hairpin. We showed the existence of intermediate states near the melting temperature. We further showed that different ensembles used to model single-molecule force spectroscopy setups may give different force-temperature diagrams. We delineate the possible reasons for the observed discrepancies. � 2023 American Physical Society.
dc.identifier.doihttps://doi.org/10.1103/PhysRevE.107.054501
dc.identifier.issn24700045
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/22402
dc.language.isoen
dc.publisherAmerican Physical Society
dc.titleForce-induced melting of DNA hairpin: Unfolding pathways and phase diagrams
dc.typeArticle
dspace.entity.typePublication
journal.titlePhysical Review E
journalvolume.identifier.volume107

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2023