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Tinospora cordifolia Leaves Derived Carbon dots for Cancer Cell Bioimaging, Free radical Scavenging, and Fe3+ Sensing Applications

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dc.contributor.authorMohapatra, Debadatta
dc.contributor.authorPratap, Ravi
dc.contributor.authorPandey, Vivek
dc.contributor.authorDubey, Pawan K.
dc.contributor.authorAgrawal, Ashish K.
dc.contributor.authorParmar, Avanish S.
dc.contributor.authorSahu, Alakh N.
dc.date.accessioned2025-01-27T10:24:14Z
dc.date.available2025-01-27T10:24:14Z
dc.date.issued2022
dc.description.abstractHerein, we report the fabrication of Tinospora cordifolia leaves-derived carbon dots (TCLCDs) from aqueous extract of leaves as carbon source via simple, environmentally friendly, hydrothermal carbonization (HTC) technique. The synthesized TCLCDs were characterized for their physicochemical properties and further explored for in-vitro cancer cell bioimaging, radical scavenging, and metal ion sensing. The synthesized TCLCDs showed excitation-dependent emission property with maximum emission at 435 nm under the excitation of 350 nm. The High-Resolution Transmission Electron Microscopy (HRTEM) results revealed a roughly spherical shape with an average diameter of 5.47 nm. The diffused ring pattern of Selected Area Electron Diffraction (SAED) and halo diffraction pattern of X-ray diffraction (XRD) disclosed their amorphous nature. The Energy Dispersive X-ray (EDX) showed the existence of C, N, and O. The Fourier-transform infrared spectroscopy (FTIR) revealed the presence of -OH, -NH, -CN, and -CH groups. The TCLCDs showed excellent cellular biocompatibility with dose-dependent bioimaging results in melanoma (B16F10) and cervical cancer (SiHa) cell lines. Also, they exhibited excellent scavenging of free radicals with an IC50 value of 0.524 mg/mL & selective Fe3+ ion sensing with a detection limit of 0.414 �M. Further, they exerted excellent bacterial biocompatibility, photostability, and thermal stability. The overall results reflected their potential for in-vitro cancer cell bioimaging, free radical scavenging, and selective Fe3+ ion sensing. � 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.doihttps://doi.org/10.1007/s10895-021-02846-6
dc.identifier.issn10530509
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/15283
dc.publisherSpringer
dc.subjectBioimaging
dc.subjectCarbon dots
dc.subjectFe<sup>3+</sup> Sensing
dc.subjectGreen chemistry
dc.subjectRadical scavenging
dc.titleTinospora cordifolia Leaves Derived Carbon dots for Cancer Cell Bioimaging, Free radical Scavenging, and Fe3+ Sensing Applications
dc.typeArticle
dspace.entity.typePublication
journal.titleJournal of Fluorescence
journalvolume.identifier.volume32

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2022