Publication:
Insights of Endocytosis Signaling in Health and Disease

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dc.contributor.authorPathak, Chandramani
dc.contributor.authorVaidya, Foram U.
dc.contributor.authorWaghela, Bhargav N.
dc.contributor.authorJaiswara, Pradip Kumar
dc.contributor.authorGupta, Vishal Kumar
dc.contributor.authorKumar, Ajay
dc.contributor.authorRajendran, Barani Kumar
dc.contributor.authorRanjan, Kishu
dc.date.accessioned2025-01-28T09:55:08Z
dc.date.available2025-01-28T09:55:08Z
dc.date.issued2023
dc.description.abstractEndocytosis in mammalian cells is a fundamental cellular machinery that regulates vital physiological processes, such as the absorption of metabolites, release of neurotransmitters, uptake of hormone cellular defense, and delivery of biomolecules across the plasma membrane. A remarkable characteristic of the endocytic machinery is the sequential assembly of the complex proteins at the plasma membrane, followed by internalization and fusion of various biomolecules to different cellular compartments. In all eukaryotic cells, functional characterization of endocytic pathways is based on dynamics of the protein complex and signal transduction modules. To coordinate the assembly and functions of the numerous parts of the endocytic machinery, the endocytic proteins interact significantly within and between the modules. Clathrin-dependent and -independent endocytosis, caveolar pathway, and receptor mediated endocytosis have been attributed to a greater variety of physiological and pathophysiological roles such as, autophagy, metabolism, cell division, apoptosis, cellular defense, and intestinal permeabilization. Notably, any defect or alteration in the endocytic machinery results in the development of pathological consequences associated with human diseases such as cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. In this review, an in-depth endeavor has been made to illustrate the process of endocytosis, and associated mechanisms describing pathological manifestation associated with dysregulated endocytosis machinery. � 2023 by the authors.
dc.identifier.doihttps://doi.org/10.3390/ijms24032971
dc.identifier.issn16616596
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/22841
dc.language.isoen
dc.publisherMDPI
dc.subjectchronic diseases
dc.subjectendocytosis
dc.subjectphagocytosis
dc.subjectpinocytosis
dc.subjectreceptor endocytosis signaling
dc.titleInsights of Endocytosis Signaling in Health and Disease
dc.typeReview
dspace.entity.typePublication
journal.titleInternational Journal of Molecular Sciences
journalvolume.identifier.volume24

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2023