Publication: Synthesis of ?-Carbonyl-??-amide Sulfoxonium Ylides from Isocyanates with Complete Atom Economy
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Date
2023
Journal Title
Organic Letters
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
An efficient catalyst- and additive-free facile synthesis of ?-carbonyl-??-amide sulfoxonium ylides from isocyanates and ?-ketosulfoxonium ylides with complete atom economy has been described. The ?-ketosulfoxonium ylides and isocyanates adorned with various functional groups were well-tolerated and afforded moderate to high yields of the ?-carbonyl-??-amide sulfoxonium ylide derivatives. Finally, using large-scale reactions and converting the synthesized ylides into other valuable compounds, we demonstrated the practicality of this synthetic method. � 2023 American Chemical Society.