Publication:
Aroyl hydrazone with large Stokes shift as a fluorescent probe for detection of Cu2+ in pure aqueous medium and in vivo studies

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dc.contributor.authorDwivedi, Romi
dc.contributor.authorSingh, Saumya
dc.contributor.authorChauhan, Brijesh Singh
dc.contributor.authorSrikrishna, S.
dc.contributor.authorPanday, Anoop Kumar
dc.contributor.authorChoudhury, Lokman H.
dc.contributor.authorSingh, Vinod Prasad
dc.date.accessioned2025-03-01T05:52:10Z
dc.date.available2025-03-01T05:52:10Z
dc.date.issued2020
dc.description.abstractAn aroyl hydrazone based fluorescent probe, hpsh, has been developed for the selective detection of Cu2+ ions in pure aqueous medium by static fluorescence quenching. The fluorescence quenching of hpsh in the presence of Cu2+ takes place as a result of ground state complex formation through intramolecular charge transfer (ICT). Addition of Cu2+ ions changes the color of the solution from colorless to yellow-green which is clearly visible by naked eye. Large Stokes shift of hpsh prevents the self-quenching of the probe in absence of metal ions. The observed stoichiometry between Cu2+ and probe has been found as 1:2 (M: L). MTT assay of hpsh on fruit flies confirms that the probe is non-toxic and biocompatible. The plausible in vivo bioimaging application of the probe to detect Cu2+ in Drosophila gut tissues as well as in adult fruit fly has been investigated with excellent results. © 2020 Elsevier B.V.
dc.identifier.doihttps://doi.org/10.1016/j.jphotochem.2020.112501
dc.identifier.issn10106030
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/67727
dc.publisherElsevier B.V.
dc.subjectBio imaging
dc.subjectFluorescent probe
dc.subjectLarge stokes shift
dc.subjectStatic quenching
dc.titleAroyl hydrazone with large Stokes shift as a fluorescent probe for detection of Cu2+ in pure aqueous medium and in vivo studies
dc.typeArticle
dspace.entity.typePublication
journal.titleJournal of Photochemistry and Photobiology A: Chemistry
journalvolume.identifier.volume395

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