Publication:
Putative role of natural products as Protein Kinase C modulator in different disease conditions

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dc.contributor.authorSingh, Rishi Kant
dc.contributor.authorKumar, Sanjay
dc.contributor.authorTomar, Munendra Singh
dc.contributor.authorVerma, Praveen Kumar
dc.contributor.authorKumar, Amit
dc.contributor.authorKumar, Sandeep
dc.contributor.authorKumar, Naveen
dc.contributor.authorSingh, Jai Prakash
dc.contributor.authorAcharya, Arbind
dc.date.accessioned2025-01-30T05:49:33Z
dc.date.available2025-01-30T05:49:33Z
dc.date.issued2021
dc.description.abstractIntroduction: Protein kinase C (PKC) is a promising drug target for various therapeutic areas. Natural products derived from plants, animals, microorganisms, and marine organisms have been used by humans as medicine from prehistoric times. Recently, several compounds derived from plants have been found to modulate PKC activities through competitive binding with ATP binding site, and other allosteric regions of PKC. As a result fresh race has been started in academia and pharmaceutical companies to develop an effective naturally derived small-molecule inhibitor to target PKC activities. Herein, in this review, we have discussed several natural products and their derivatives, which are reported to have an impact on PKC signaling cascade. Methods: All information presented in this review article regarding the regulation of PKC by natural products has been acquired by a systematic search of various electronic databases, including ScienceDirect, Scopus, Google Scholar, Web of science, ResearchGate, and PubMed. The keywords PKC, natural products, curcumin, rottlerin, quercetin, ellagic acid, epigallocatechin-3 gallate, ingenol 3 angelate, resveratrol, protocatechuic acid, tannic acid, PKC modulators from marine organism, bryostatin, staurosporine, midostaurin, sangivamycin, and other relevant key words were explored. Results: The natural products and their derivatives including curcumin, rottlerin, quercetin, ellagic acid, epigallocatechin-3 gallate, ingenol 3 angelate, resveratrol, bryostatin, staurosporine, and midostaurin play a major role in the management of PKC activity during various disease progression. Conclusion: Based on the comprehensive literature survey, it could be concluded that various natural products can regulate PKC activity during disease progression. However, extensive research is needed to circumvent the challenge of isoform specific regulation of PKC by natural products. � 2021, Springer Nature Switzerland AG.
dc.identifier.doihttps://doi.org/10.1007/s40199-021-00401-z
dc.identifier.issn15608115
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/24154
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.subjectCancer
dc.subjectCardiac�disease
dc.subjectDrug target
dc.subjectNatural products
dc.subjectNeurodegenerative diseases
dc.titlePutative role of natural products as Protein Kinase C modulator in different disease conditions
dc.typeReview
dspace.entity.typePublication
journal.titleDARU, Journal of Pharmaceutical Sciences
journalvolume.identifier.volume29

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2021