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Desfechos de crian�as com s�ndrome nefr�tica idiop�tica c�rtico-resistente: um estudo observacional de centro �nico; [Outcomes of children with idiopathic steroid resistant nephrotic syndrome: a single centre observational study]

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dc.contributor.authorMishra, Om P.
dc.contributor.authorSidar, Minketan
dc.contributor.authorBatra, Vineeta V.
dc.contributor.authorPrasad, Rajniti
dc.contributor.authorSingh, Ankur
dc.contributor.authorAbhinay, Abhishek
dc.contributor.authorMishra, Akash
dc.contributor.authorYadav, Ashish K.
dc.date.accessioned2025-01-28T10:04:16Z
dc.date.available2025-01-28T10:04:16Z
dc.date.issued2023
dc.description.abstractIntroduction: Idiopathic steroid resistant nephrotic syndrome (SRNS) has variable outcomes in children. The primary objective of the present study was to assess the cumulative remission rate and the secondary objectives were to assess factors affecting the remission status, kidney function survival, and adverse effects of medications. Methods: One hundred fourteen patients with SRNS were included. Calcineurin inhibitor-based treatment protocol along with prednisolone and angiotensin-converting enzyme inhibitor were used, and patients were followed over 5 years. Results: Median age was 4.5 years; 53.5% of cases were between 1 to 5 years of age. Sixty-two patients (54.4%) were at initial stage and 52 (45.6%) were at a late SRNS stage. Median eGFRcr was 83.5 mL/min/1.73m2 at presentation. Of the 110 patients, 63 (57.3%) achieved remission [complete remission 30 (27.3%), partial remission 33 (30%)], and 47 (42.7%) had no remission. Kidney function survival was 87.3% and 14 cases (12.7%) had progression to CKD (G3-8, G4-3, G5-1, and G5D-2). Median duration of follow up was 36 months (IQR 24, 60). Age of onset, cyclosporine/tacrolimus, eGFRcr, and histopathology (MCD/FSGS) did not affect remission. Similarly, remission status in addition to age of onset, drug protocol, and histopathology did not significantly affect kidney function during a period of 5 years. Hypertension, cushingoid facies, short stature, cataract, and obesity were observed in 37.7, 29.8, 25.5, 17.5, and 0.7% of cases, respectively. Conclusion: About half of the cases achieved remission. Age of onset of disease, cyclosporine/tacrolimus use, and histopathological lesion neither affected remission status nor short-term kidney function survival in SRNS. � 2023 The Author(s).
dc.identifier.doihttps://doi.org/10.1590/2175-8239-JBN-2022-0073en
dc.identifier.issn1012800
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/23444
dc.language.isoen
dc.publisherSociedade Brasileira de Nefrologia
dc.subjectKidney Function survival
dc.subjectNephrotic Syndrome
dc.subjectRemission
dc.subjectSteroid resistant
dc.titleDesfechos de crian�as com s�ndrome nefr�tica idiop�tica c�rtico-resistente: um estudo observacional de centro �nico; [Outcomes of children with idiopathic steroid resistant nephrotic syndrome: a single centre observational study]
dc.typeBook chapter
dspace.entity.typePublication
journal.titleBrazilian Journal of Nephrology
journalvolume.identifier.volume45

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