Publication:
Fungal Endophytes: an Accessible Source of Bioactive Compounds with Potential Anticancer Activity

Simple item page
dc.contributor.authorRai, Nilesh
dc.contributor.authorGupta, Priyamvada
dc.contributor.authorKeshri, Priyanka Kumari
dc.contributor.authorVerma, Ashish
dc.contributor.authorMishra, Pradeep
dc.contributor.authorKumar, Deepak
dc.contributor.authorKumar, Ajay
dc.contributor.authorSingh, Santosh Kumar
dc.contributor.authorGautam, Vibhav
dc.date.accessioned2025-01-27T09:58:39Z
dc.date.available2025-01-27T09:58:39Z
dc.date.issued2022
dc.description.abstractEndophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host plants without showing any immediate negative effects on them. Among numerous natural alternative sources, fungal endophytes produce a wide range of structurally diverse bioactive metabolites including anticancer compounds. Considering the production of bioactive compounds in low quantity, genetic and physicochemical modification of the fungal endophytes is performed for the�enhanced production�of�bioactive compounds. Presently, for the treatment of cancer, chemotherapy is majorly used, but the side effects of chemotherapy are of prime concern in clinical practices. Also, the drug-resistant properties of carcinoma cells, lack of cancer cells-specific medicine, and the side effects of drugs are the biggest obstacles in cancer treatment. The interminable requirement of potential drugs has encouraged researchers to seek alternatives to find novel bioactive compounds, and fungal endophytes seem to be a probable target for the discovery of anticancer drugs. The present review focuses a comprehensive literature on the major fungal endophyte-derived bioactive compounds which are presently been used for the management of cancer, biotic factors influencing the production of bioactive compounds and about the challenges in the field of fungal endophyte research. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
dc.identifier.doihttps://doi.org/10.1007/s12010-022-03872-1
dc.identifier.issn2732289
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/13618
dc.publisherSpringer
dc.subjectAnticancer activity
dc.subjectBioactive compound
dc.subjectEpigenetic modifier
dc.subjectFungal endophytes
dc.subjectPaclitaxel
dc.subjectPodophyllotoxin
dc.titleFungal Endophytes: an Accessible Source of Bioactive Compounds with Potential Anticancer Activity
dc.typeReview
dspace.entity.typePublication
journal.titleApplied Biochemistry and Biotechnology
journalvolume.identifier.volume194

Files

Collections

2022