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Mitochondrial pathway mediated apoptosis and cell cycle arrest triggered by cobalt(III) complex in Dalton�s lymphoma cells

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dc.contributor.authorVerma, Praveen Kumar
dc.contributor.authorGond, Mannu Kumar
dc.contributor.authorBharty, Manoj Kumar
dc.contributor.authorAcharya, Arbind
dc.date.accessioned2025-01-30T05:53:36Z
dc.date.available2025-01-30T05:53:36Z
dc.date.issued2021
dc.description.abstractCancer is a group of diseases which evolves from uncontrolled growth of abnormal cells. It has become the second leading cause of death worldwide. Many platinum-based compounds like cisplatin and carboplatin are widely used as a therapeutic approach against cancer, but patients are resistant to these therapeutic agents with life-threatening side effects. In this study, we used a non-platinum-based compound, i.e. cobalt complex, on the Dalton�s lymphoma cells (DL cells). It is a tumor model of murine T-cell lymphoma of thymic genesis, which is very aggressive. The present study was focused on evaluating the anticancer efficacy of cobalt complex on DL cells. The IC50 value of cobalt complex was found to be 80 �3.21 �M in DL cells�. In addition, cobalt complex promoted condensed nuclei, G1 phase arrest, and induced early and late apoptotic cells. Additionally, flow cytometry examination showed a significant loss in mitochondrial membrane potential and induction of reactive oxygen species after treatment. Furthermore, Western blot revealed the increased p53, cyt-c, Bax protein, and decreased Bcl2 protein level in treated DL cells. These results verified the anticancer properties of cobalt(III) complex against DL cells and propose an alternative therapeutic drug in cancer treatment. � 2021. Praveen Kumar Verma et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
dc.identifier.doihttps://doi.org/10.7324/JAPS.2021.1101002
dc.identifier.issn22313354
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/24411
dc.publisherOpen Science Publishers LLP Inc.
dc.subjectAnti-tumor activity
dc.subjectapoptosis
dc.subjectcobalt complex
dc.subjectDalton�s lymphoma
dc.subjectreactive oxygen species
dc.titleMitochondrial pathway mediated apoptosis and cell cycle arrest triggered by cobalt(III) complex in Dalton�s lymphoma cells
dc.typeArticle
dspace.entity.typePublication
journal.titleJournal of Applied Pharmaceutical Science
journalvolume.identifier.volume11

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2021