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Antimicrobial Potential of Essential Oils from Aromatic Plant Ocimum sp.; A Comparative Biochemical Profiling and In-Silico Analysis

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dc.contributor.authorSalvi, Prafull
dc.contributor.authorKumar, Gulshan
dc.contributor.authorGandass, Nishu
dc.contributor.authorKajal
dc.contributor.authorVerma, Ashish
dc.contributor.authorRajarammohan, Sivasubramanian
dc.contributor.authorRai, Nilesh
dc.contributor.authorGautam, Vibhav
dc.date.accessioned2025-01-27T10:05:59Z
dc.date.available2025-01-27T10:05:59Z
dc.date.issued2022
dc.description.abstractMedicinal and aromatic plants (MAPs) are a rich source of bioactive compounds that are immensely important due to their potential use in pharmacological and agricultural applications. Here, we have evaluated the antimicrobial activity of essential oils (EOs) from three different species of Ocimum: O. gratissimum (EO1), O. tenuiflorum (EO2), and O. sanctum (EO3). The EOs were screened for antibacterial activity against pathogenic strains of Escherichia coli, Enterobacter cloacae and methicillin-resistant Staphylococcus aureus (MRSA). The essential oils EO1 and EO3 showed significant growth inhibition of the tested bacteria. Likewise, all EOs exhibited antifungal potential against the broad-spectrum plant fungal pathogen Sclerotinia sclerotiorum that causes white-mould disease in plants. Moreover, the antimicrobial potential of the EOs correlates well with their antioxidant activity determined by DPPH free radical scavenging activity. The biochemical analysis of the EOs employing high-performance thin-layer chromatography, gas chromatography-mass spectrometry, and Fourier transform infrared spectroscopy, revealed the presence of distinct phytoconstituents that might be responsible for their differential bioactivity. Furthermore, an in-silico evaluation of the candidate phytoconstituents using molecular docking analysis suggests their potential for antimicrobial applications. Altogether, our results clearly show that EO1 and EO3 possess promising antimicrobial properties, and therefore could be utilized as a potential antimicrobial agent. � 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.identifier.doihttps://doi.org/10.3390/agronomy12030627
dc.identifier.issn20734395
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/14045
dc.publisherMDPI
dc.subjectAntimicrobial
dc.subjectCrop protection
dc.subjectEssential oil
dc.subjectFTIR
dc.subjectGC-MS
dc.subjectHPTLC
dc.subjectMolecular docking
dc.subjectOcimum sp
dc.titleAntimicrobial Potential of Essential Oils from Aromatic Plant Ocimum sp.; A Comparative Biochemical Profiling and In-Silico Analysis
dc.typeArticle
dspace.entity.typePublication
journal.titleAgronomy
journalvolume.identifier.volume12

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2022