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Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism

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dc.contributor.authorTiwari, Rajan Kumar
dc.contributor.authorRawat, Shiv Govind
dc.contributor.authorGupta, Vishal Kumar
dc.contributor.authorJaiswara, Pradip Kumar
dc.contributor.authorSonker, Pratishtha
dc.contributor.authorKumar, Santosh
dc.contributor.authorGautam, Vibhav
dc.contributor.authorMishra, Manoj K.
dc.contributor.authorKumar, Ajay
dc.date.accessioned2025-01-28T09:56:41Z
dc.date.available2025-01-28T09:56:41Z
dc.date.issued2023
dc.description.abstractIn recent years, studies have reported the role of stress-regulatory hormones, including epinephrine, in regulating the progression of a few cancers. However, the tumor-promoting action of epinephrine is not yet investigated in T cell malignancy, a rare and complicated neoplastic disorder. More so, very little is known regarding the implication of epinephrine in the glucose metabolic rewiring in tumor cells. The present investigation showed that epinephrine enhanced the proliferation of T lymphoma cells through up- and down-regulating the expression of PCNA, cyclin D, and p53, respectively. In addition, epinephrine inhibited apoptosis in T lymphoma cells possibly by increasing the level of BCL2 (an anti-apoptotic protein) and decreasing PARP level (a pro-apoptotic protein). Intriguingly, epinephrine is reported to stimulate glycolysis in T lymphoma cells by increasing the expression of crucial glycolysis regulatory molecules, namely HKII and PKM2, in a HIF-1?-dependent manner. Moreover, augmented production of ROS has been observed in T lymphoma cells, which might be a central player in epinephrine-mediated T cell lymphoma growth. Taken together, our study demonstrates that epinephrine might have a significant role in the progression of T cell lymphoma. � 2022
dc.identifier.doihttps://doi.org/10.1016/j.cbi.2022.110278
dc.identifier.issn92797
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/22929
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectApoptosis
dc.subjectCell proliferation
dc.subjectEpinephrine
dc.subjectGlycolysis
dc.subjectReactive oxygen species
dc.subjectT cell lymphoma
dc.titleEpinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism
dc.typeArticle
dspace.entity.typePublication
journal.titleChemico-Biological Interactions
journalvolume.identifier.volume369

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