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Hospital based prospective longitudinal clinical and immunologic study of 179 patients of primary anti-phospholipid syndrome

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dc.contributor.authorSingh, Nand K.
dc.contributor.authorBehera, Dibya R.
dc.contributor.authorAgrawal, Ankit
dc.contributor.authorSingh, Mahendra Narayan
dc.contributor.authorKumar, Vikash
dc.contributor.authorGodhra, Manoj
dc.contributor.authorGupta, Anurag
dc.contributor.authorYadav, Devesh P.
dc.contributor.authorSingh, Usha
dc.contributor.authorPandey, Lakshmi Kant
dc.contributor.authorMatah, Manjari
dc.date.accessioned2025-02-20T10:08:09Z
dc.date.available2025-02-20T10:08:09Z
dc.date.issued2013
dc.description.abstractAim: To study the clinical and immunological features of primary antiphospholipid syndrome (APS), and to analyze the differences between primary APS and APS associated with autoimmune rheumatic disease (ARD/APS). Methods: This prospective, longitudinal study, carried out from December 2004 to July 2011 included 179 patients with primary APS and 52 patients of ARD/APS diagnosed as per modified 2006 Sapporo's Criteria. Results: Out of 179 patients of primary APS, 12 were male and 167 were female. The mean age at the time of study entry was 27 � 4.33 years. Venous thrombosis was noted in 33 (18.43%) patients. Seventeen patients had deep vein thrombosis and 11 (7.19%) had cortical vein and/or cortical sinus thrombosis. Arterial thrombosis was noted in 19 (10.61%) patients, out of which nine had intracranial arterial thrombosis. Thirty-two (17.85%) had recurrent early fetal losses (< 10 weeks) and 97 (54.18%) had late fetal loss (> 10 weeks). Immunoglobulin G (IgG) and IgM aCLA were present in 141 (78.77%) and 32 (17.87%) patients respectively, whereas lupus anticoagulant was present in 99 (55.3%) patients. In patients with bad obstetric outcome, lupus anticoagulant positivity was significantly more prevalent (P < 0.05) than aCLA positivity. Both venous and arterial thrombosis were significantly more common (P < 0.05) in ARD/APS. However, late fetal loss was significantly more prevalent (P < 0.001) in primary APS. Conclusion: Primary APS may lead to a variety of clinical manifestations due to venous and/or arterial thrombosis, which at times may be lethal. It is also an important cause of early and late pregnancy loss(es) and other pregnancy morbidities. � 2013 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.
dc.identifier.doihttps://doi.org/10.1111/1756-185X.12150
dc.identifier.issn1756185X
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/43511
dc.subjectAnti-phospholipid syndrome
dc.subjectPregnancy loss
dc.subjectVenous and arterial thrombosis
dc.titleHospital based prospective longitudinal clinical and immunologic study of 179 patients of primary anti-phospholipid syndrome
dc.typeArticle
dspace.entity.typePublication
journal.titleInternational Journal of Rheumatic Diseases
journalvolume.identifier.volume16

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2013