Publication:
Advancements and Challenges in Developing Malaria Vaccines: Targeting Multiple Stages of the Parasite Life Cycle

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dc.contributor.authorRajneesh, None
dc.contributor.authorTiwari, Rahul
dc.contributor.authorSingh, Vishal K.
dc.contributor.authorKumar, Awnish
dc.contributor.authorGupta, Rohit P.
dc.contributor.authorSingh, Akhilesh K.
dc.contributor.authorGautam, Vibhav
dc.contributor.authorKumar, Rajiv
dc.date.accessioned2025-01-28T09:33:49Z
dc.date.available2025-01-28T09:33:49Z
dc.date.issued2023
dc.description.abstractMalaria, caused by Plasmodium species, remains a major global health concern, causing millions of deaths annually. While the introduction of the RTS,S vaccine has shown promise, there is a pressing need for more effective vaccines due to the emergence of drug-resistant parasites and insecticide-resistant vectors. However, the complex life cycle and genetic diversity of the parasite, technical obstacles, limited funding, and the impact of the 2019 pandemic have hindered progress in malaria vaccine development. This review focuses on advancements in malaria vaccine development, particularly the ongoing clinical trials targeting antigens from different stages of the Plasmodium life cycle. Additionally, we discuss the rationale, strategies, and challenges associated with vaccine design, aiming to enhance the immune response and protective efficacy of vaccine candidates. A cost-effective and multistage vaccine could hold the key to controlling and eradicating malaria. � 2023 American Chemical Society.
dc.identifier.doihttps://doi.org/10.1021/acsinfecdis.3c00332
dc.identifier.issn23738227
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/21577
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subjectCHMI
dc.subjectclinical trials
dc.subjectimmune response
dc.subjectlife-cycle
dc.subjectmalaria
dc.subjectmultivalent vaccines
dc.subjectPlasmodium
dc.subjectprotective efficacy
dc.subjectRTS,S
dc.subjectvaccine development
dc.titleAdvancements and Challenges in Developing Malaria Vaccines: Targeting Multiple Stages of the Parasite Life Cycle
dc.typeReview
dspace.entity.typePublication
journal.titleACS Infectious Diseases
journalvolume.identifier.volume9

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2023