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Beyond the synthetic drugs: Fungal endophytes derived bioactive compounds in the management of neurodegenerative disorders

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dc.contributor.authorVerma, Ashish
dc.contributor.authorRai, Nilesh
dc.contributor.authorKamble, Swapnil C.
dc.contributor.authorMishra, Pradeep
dc.contributor.authorBarik, Suvakanta
dc.contributor.authorKumar, Rajiv
dc.contributor.authorSingh, Santosh Kumar
dc.contributor.authorSalvi, Prafull
dc.contributor.authorGautam, Vibhav
dc.date.accessioned2025-01-28T09:51:49Z
dc.date.available2025-01-28T09:51:49Z
dc.date.issued2023
dc.description.abstractFungal endophytes are a group of fungi that reside in plant tissues and show a symbiotic relationship with the host plants. They protect against pathogens and increase food availability without causing any harmful effects on the host plant. Fungal endophytes are known to produce a wide range of bioactive compounds with several biological activities, including neuroprotective effects. Neurodegenerative disorders lead to miscommunication between nerve cells, damage or loss in structure and function of the central nervous system (CNS) or peripheral nervous system (PNS). Reactive oxygen species, neuroinflammation, protein degradation or aggregation, familial history, mutation in mitochondrial genes, and aging contribute to neurodegenerative disorders. Plant-associated fungal endophytes produce bioactive compounds, which show anti-neuroinflammatory, antioxidant, and anti-cholinesterase activities. Several pro-inflammatory (TNF-? and NF-?B) and depressant (serotonin, dopamine, and noradrenaline) molecules or neuronal signaling pathways leading to neurodegenerative disorders are known to be inhibited or down-regulated by fungal endophyte-derived bioactive compounds. Therefore, bioactive compounds produced from fungal endophytes could be a promising approach to treating various health ailments. The present chapter discusses selected fungal endophyte-derived potential bioactive compounds with neuroprotective effects for managing neurodegenerative disorders. � 2023 Bentham Science Publishers. All rights reserved.
dc.identifier.doihttps://doi.org/10.2174/9789815040197123010007
dc.identifier.isbn978-981504019-7; 978-981504020-3
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/22672
dc.language.isoen
dc.publisherBentham Science Publishers
dc.subjectDepression
dc.subjectFungal endophytes
dc.subjectNeurodegenerative disorders
dc.subjectNeuroinflammation
dc.subjectOxidative stress
dc.titleBeyond the synthetic drugs: Fungal endophytes derived bioactive compounds in the management of neurodegenerative disorders
dc.typeBook chapter
dspace.entity.typePublication
journal.titleTraditional Medicine for Neuronal Health

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