Publication: Multicomponent Synthesis of S-Benzyl Dithiocarbamates from para-Quinone Methides and Their Biological Evaluation for the Treatment of Alzheimer�s Disease
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Date
2022
Journal Title
Journal of Organic Chemistry
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Multicomponent synthesis of biologically relevant S-benzyl dithiocarbamates from para-quinone methides, amines, and carbon disulfide are described under catalyst and additive-free conditions. The reactions proceeded at room temperature in a short span of time with excellent yields. One of the synthesized compounds, 3e showed considerable acetylcholinesterase (AChE) inhibitory (51.70 + 5.63% at 20 ?m) and antioxidant (63.52 � 1.15 at 20 ?m) activities. � 2022 American Chemical Society.