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Preparation, characterization and performance of a silica gel bonded molecularly imprinted polymer for selective recognition and enrichment of β-lactam antibiotics

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dc.contributor.authorPrasad, Bhim Bali
dc.contributor.authorBanerjee, Shouri
dc.date.accessioned2025-03-04T06:21:30Z
dc.date.available2025-03-04T06:21:30Z
dc.date.issued2003
dc.description.abstractA silica gel-bound molecularly imprinted polymer to oxazolone(s) exclusively derived from certain cephalosporins (cefaclor) and penicillins (amoxycillins and ampicillins) was prepared using ethylacetate as a porogen. This was used as a packing material for solid phase extraction in column chromatography. The high selectivity and the quantitative sorption of oxazolone at pH 7.5 and a flow rate of 5.0 ml min-1 in a long (13.0 cm) and wide bore (1.4 cm internal diameter) column have led to efficient clean-up, selective enrichment, and indirect differential pulse adsorptive stripping voltammetric measurement of the β-lactams in the form of corresponding oxazolones either in a larger volume of dilute aqueous systems or in the pharmaceutical formulations, without complications of complex matrices, excipients or column deterioration. © 2003 Elsevier Science B.V. All rights reserved.
dc.identifier.doihttps://doi.org/10.1016/S1381-5148(02)00225-0
dc.identifier.issn13815148
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/88457
dc.subjectColumn chromatographic separations
dc.subjectMolecularly imprinted polymer-modified silica gel
dc.subjectSelective enrichment
dc.subjectStripping voltammetry
dc.subjectβ-Lactams
dc.titlePreparation, characterization and performance of a silica gel bonded molecularly imprinted polymer for selective recognition and enrichment of β-lactam antibiotics
dc.typeArticle
dspace.entity.typePublication
journal.titleReactive and Functional Polymers
journalvolume.identifier.volume55

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2003