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CRISPR/Cas9 mediated genome editing tools and their possible role in disease resistance mechanism

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dc.contributor.authorKumari, Diksha
dc.contributor.authorPrasad, Bishun Deo
dc.contributor.authorDwivedi, Padmanabh
dc.contributor.authorHidangmayum, Akash
dc.contributor.authorSahni, Sangita
dc.date.accessioned2025-01-27T09:42:06Z
dc.date.available2025-01-27T09:42:06Z
dc.date.issued2022
dc.description.abstractSeveral phytopathogens have detrimental effects on crop production and productivity potentially threatening global food security. Studying the genetic mechanisms of virulence in phytopathogens is vital to assist in their management. Genome editing tools are paving their fascinating roles from the first-generation site-specific nucleases ZNF and TALEN to the current generation clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein9. The discovery of CRISPR/Cas9 has revolutionised the understanding of resistance as well as the susceptibility mechanism against phytopathogens in crop plants. This emerging tool allows researchers to perform precise genome manipulation, genetic screening, regulation, and correction to develop resistance in crop plants with fewer off-target effects. It provides a new opportunity for disease improvement and strengthens the resistant breeding programme. CRISPR/Cas9-based targeted gene manipulation and its enormous application potential as well as the challenges for developing transgene-free disease-resistant crop plants have been discussed in this review. � 2022, The Author(s), under exclusive licence to Springer Nature B.V.
dc.identifier.doihttps://doi.org/10.1007/s11033-022-07851-x
dc.identifier.issn3014851
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/12693
dc.publisherSpringer Science and Business Media B.V.
dc.subjectCRISPR/Cas9
dc.subjectDisease resistant
dc.subjectGenome editing
dc.subjectTALEN
dc.subjectZNF
dc.titleCRISPR/Cas9 mediated genome editing tools and their possible role in disease resistance mechanism
dc.typeArticle
dspace.entity.typePublication
journal.titleMolecular Biology Reports
journalvolume.identifier.volume49

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