Browsing by Author "K. Sharma"

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A New Cucurbitacin Glucoside from Luffa graveolense
(Springer Science and Business Media, LLC, 2019) S. Kumar; K. Sharma; M. Sahai; R. Maurya
A new cucurbitacin glucoside has been isolated from an ethanolic extract of Luffa graveolense, along with four known cucurbitacins. Its structure has been assigned as 20-O-β-D-glucopyranosyl cucurbitacin B (2) by spectroscopic analysis. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Basic Principles of Pediatric Surgical Oncology: What Radiologist Should Know
(Springer Science+Business Media, 2025) K. Sharma; Sarita Chowdhary; Shiv Prasad Sharma; Ishan Kumar
Radiologists are integral members in the multidisciplinary care of pediatric oncology patients. Their expertise in diagnostic imaging, including X-rays, ultrasounds, MRIs, and CT scans, is essential for accurate diagnosis and treatment planning. Interpretation and diagnosis of pediatric surgical imaging require a comprehensive understanding of imaging algorithms to navigate between various tumors. The location, size, and characteristics of these abnormalities are crucial in determining the type and extent of the cancer. Surgical planning is predominantly guided by resectability and stage of tumor. Further, imaging plays a crucial role in assessing the treatment response as well as long-term surveillance of tumor. This review explores the treatment guidelines and protocols of common pediatric surgical tumors. A concise algorithms to various pediatric surgical tumors have been provided to give insight into the integrated treatment approach with approximate timelines. © 2025 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
Comparative nutritional evaluation of raw and detoxified karanj (Pongamia glabra) cake by in vitro gas production technique
(Indian journals, 2016) V.K. Paswan; Narayan Dutta; A.K. Pattanaik; K. Sharma
Karanj (Pongamia glabra) cake is an important proteinaceous feeding resource for livestock available as by-product from biodiesel industry. However, its use in livestock feeding is restricted due to the presence of toxic principles. A suitable method of detoxification of karanj cake was evolved which resulted into substantial removal of major toxins viz., karanjin, pongamol and trypsin inhibitors while preserving its nutrients. Further, both raw and detoxified karanj cake were subjected to in vitro study by incorporation at 0 (control), 12.5, 25.0, 37.5, 50.0, 62.5, 75.0, 87.5 and 100 percent levels by replacing soybean meal in the concentrate mixtures (22% CP) on protein equivalent basis. Concentrate mixtures and fine ground wheat straw (1:1 on weight basis) was used as substrate for in vitro study. The substrate degradation in terms of gas volume produced in 24 h (ml/200 mg), truly degradable organic matter in rumen (TDOMR; mg/200 mg), TDOMR%, partitioning factor, microbial biomass production (MBP; mg/200 mg) and efficiency of microbial biomass production (MBP/100 mg TDOMR) were found to be comparable (P > 0.05) for both raw and detoxified karanj cake. It may be concluded that complete replacement of soybean meal with either raw or detoxified karanj cake in vitro did not exert any adverse effect on substrate degradation and efficiency of microbial biomass production.
Exploratory studies on the detoxification of karanj cake through various processing techniques
(Indian journals, 2020) V.K. Paswan; Narayan Dutta; A.K. Pattanaik; K. Sharma
The present study aimed at ascertaining the comparative efficacy ofdetoxification of karanj (Pongamia glabra) cake through a combination of chemical and physical processing methods. The chemical treatments involved use of organic solvents (methanol and n-hexane) and dilute acids (1-1.5% HCl and glacial acetic acid) while the physical processing methods involved refluxing, cold maceration with agitation, soaking and finally drying. The efficacies of various detoxification methods applied were evaluated on the basis of the extent to which it has reduced the toxins along with possible alterations in its nutritive potential. Among all the chemical treatments employed, cold maceration with methanol along with agitation resulted in maximum reduction of karanjin (51% reduction; 0.25% vs. 0.51% in raw karanj cake). Maximum removal of pongamol (0.095% in original to non-detectable level) was observed upon soaking the karanj cake with methanol followed by water soaking. The acid treatments with hydrochloric and glacial acetic acids significantly (P<0.05) reduced trypsin inhibitor activity; however, levels of karanjin and pongamol remained unchanged. Maximum reduction in trypsin inhibitor activity (82% reduction; 5.40 vs. 30.06TIU/ mg of protein) was observed in detoxification method involving treatment with hydrochloric acid for 12h. None of the treatment attempted could alone reduce the level of all the three major toxins to maximal reduction level. Treatment with organic solvent led to substantial removal of karanjin and pongamol, but treatment with hydrochloric and glacial acetic acid reduced trypsin inhibitor activity substantially. It was concluded that, a combination of organic solvent treatment and acid or heat treatment has the potential to remove all the three major toxins of karanj cake. © 2019 Indian journals.
Median Scrotal Mass in a Child Masquerading as Third Testis: A Diagnostic Dilemma
(Wolters Kluwer Medknow Publications, 2025) K. Sharma; Akash Mishra; Rajat Kumar Singh; Ajit Kumar Vidhyarthy; Sarita Chowdhary
[No abstract available]
Spontaneous Evisceration following Ruptured Umbilical Hernia Abscess in an Infant: A Rare Case Report
(Wolters Kluwer Medknow Publications, 2025) Greeshma Suresh; Seth Kachhap; Ajit Kumar Vidhyarthy; K. Sharma; Sarita Chowdhary
Umbilical hernia is one of the most common congenital anomalies. We document an unusual event of abscess of umbilical hernia in a 5-month-old female which was associated with rupture of the hernia followed by evisceration. Immediate reduction and surgical repair were done. The case reports an uncommon trilogy of rupture of umbilical hernia, abscess, and spontaneous evisceration. © 2025 Journal of Indian Association of Pediatric Surgeons.
Studies in spiro-heterocycles. Part-XII. Synthesis of some fluorine containing spiro [3H-indole-3,4 (4H)-pyrano [2,3-d] pyrimidine]-2,5,7 (1H)-triones as CNS agents
(1988) K.C. Joshi; R. Jain; K. Sharma; S.K. Bhattacharya; R.K. Goel
[No abstract available]
Urinary KIM-1 and CA 19-9: Biomarkers for Guiding Treatment Decisions after Pyeloplasty
(Tehran University of Medical Sciences, 2025) Sunil Kumar Singh Gaur; K. Sharma; Sarita Chowdhary; Shiv Prasad Sharma; Pranay Panigrahi
Introduction Urinary biomarkers KIM-1 and CA 19-9 are being evaluated as diagnostic indicators for congenital obstructive hydronephrosis in pediatric patients. This study focuses on the quantification of these biomarkers pre-and post-surgery, correlating their levels with ultrasonographic findings and histopathological assessments to refine diagnostic accuracy and therapeutic approaches. Biomarker analysis aids in identifying candidates for surgical intervention and addresses the challenge of persistent obstruction following pyeloplasty, facilitating timely, targeted treatments to safeguard renal function. Methods This two-year prospective analysis examined urinary KIM-1 and CA 19-9 concentrations in 40 pediatric patients diagnosed with UPJO. The study cohort included individuals below 16 years of age, provided follow-up consent was obtained. A total of three cases were excluded due to either loss to follow-up or the necessity for repeat surgical intervention. Urine specimens were collected at baseline (pre-operative) and at 1, 3, and 6 months’ post-operative intervals, with biomarker quantification conducted using ELISA kits. Diagnostic evaluation included ultrasonography and nuclear imaging modalities. Statistical analyses were performed, and significance was established at P-value<0.05. Results The study included 37 cases of UPJO requiring pyeloplasty, alongside healthy controls. Among the cases, 51.3% were children aged 1–5 years, with a male predominance of 81.08%. Post-operative outcomes demonstrated a statistically significant reduction in the antero-posterior diameter (APD). Urinary biomarkers KIM-1 and CA 19-9 exhibited a notable post-operative decline, with KIM-1 showing a more substantial decrease. The sensitivity and specificity of CA 19-9 marginally exceeded those of KIM-1. Conclusions Urinary biomarkers KIM-1 and CA 19-9 effectively monitor pyeloplasty outcomes in children with congenital obstructive hydronephrosis, providing a cost-effective, child-friendly alternative to renal scans, ensuring timely interventions, safeguarding kidney function, and reassuring families. © 2025 Urology Research Center (URC), Tehran University of Medical Sciences.
Viral spillover to humans: could Langya (LayV) virus cause a pandemic?
(Oxford University Press, 2023) S.K. Patel; K. Sharma; A. Agrawal; K.C. Nikhil; A.K. Niranjan; M.K. Pandey; N. Arya; M. Murali; J. Rana; S.P. Tiwari
[No abstract available]