2025

Now showing 1 - 2 of 2

Fluorescent Calcium Nanocluster-Driven Theranostic Nanoplatforms for Advanced Imaging and Therapy in Breast Tumor
(American Chemical Society, 2025) Abhishesh Kumar Mehata; Vivek Kumar Verma; Virendra Pratap Singh; Aseem Setia; None Vikas; Matte Kasi Viswanadh; Shivesh Sabbarwal; Manoj Kumar; Biplob Koch; Madaswamy Sona S Muthu
Biocompatible CaCO3 nanoclusters were prepared by using a simple biomineralization technique. Employing CaCO3 nanoclusters in breast cancer treatment provides an exciting avenue for theranostics, which merges precise imaging with individualized treatment plans. They were highly suitable for improving the efficacy and precision of breast cancer detection and therapy with minimal adverse effects due to their biocompatibility, controlled drug release, pH sensitivity, and adaptability. In our current study, we proposed a palbociclib (PBB)-loaded fluorescent calcium nanocluster-based redox-sensitive drug delivery system for efficient breast cancer imaging and therapy. The developed nanoparticles were analyzed for their morphology and various physicochemical properties. The particle sizes of the formulated FNC-PBB-CS-NPs (nonredox-sensitive) and FNC-PBB-CS-SS-NPs (redox-sensitive) nanoparticles were 150.2 ± 2.1 and 160.4 ± 1.4 nm, respectively. The zeta potential of nonredox-sensitive nanoparticles was measured to be +17.12 ± 1.34 mV, while the zeta potential of redox-sensitive nanoparticles was +14.32 ± 1.17 mV. The entrapment efficiencies of FNC-PBB-CS-NPs and FNC-PBB-CS-SS-NPs were determined to be 88.74 ± 2.34 and 89.26 ± 1.21%, respectively. FNC-PBB-CS-SS-NPs demonstrated quicker drug release at acidic pH compared to FNC-PBB-CS-NPs. The cytotoxicity assay conducted on MCF-7 and T-47D cells indicated that FNC-PBB-CS-NPs and FNC-PBB-CS-SS-NPs exhibited greater cytotoxicities than free PBB. Furthermore, the Hoechst/PI dual-staining experiment demonstrated the superior activity of FNC-PBB-CS-SS-NPs over FNC-PBB-CS-NPs and free PBB. Ultrasound/photoacoustic imaging revealed that FNC-PBB-CS-SS-NPs effectively reduced tumor size, hypoxic tumor regions, and tumor vascularity compared to FNC-PBB-CS-NPs and free PBB. Additionally, in vivo optical imaging showed that the FNC-PBB-CS-SS-NPs accumulated more specifically in tumors than the other formulations. © 2025 American Chemical Society.
Development of a Self-Healing, Tissue-Adhesive, and Bacteriostatic Guar Gum-Based Hydrogel for Enhanced Wound Healing and Tissue Regeneration
(American Chemical Society, 2025) Sheetal Jaiswal; Vijay K. Sharma; Deepak Kumar; Paramjeet Yadav; Biplob Koch; Satish K. Verma; Mayank Varshney; Rajesh Rakesh Kumar
A guar gum (GG)-grafted-(polydimethylamino-co-polyacrylamido sulfonic acid) [GG-g-(PDMAEA-co-PAMPS)] hydrogel was developed as a promising material for wound dressings. The hydrogel was synthesized by grafting poly(dimethylaminoethacrylate) (PDMAEA) and poly(acrylamidopropyl sulfonic acid) (PAMPS) onto guar gum (GG), and its structure was confirmed by Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses. Rheological assessments demonstrated its mechanical robustness and self-healing properties while swelling studies revealed pH-sensitive behavior. Biocompatibility was confirmed through cell viability assays, showing minimal cytotoxicity and the hydrogel exhibited a bacteriostatic effect against Escherichia coli, Staphylococcus aureus, and Enterococcus faecalis. In a rat full-thickness chronic wound model, the hydrogel significantly accelerated wound healing, enhanced collagen deposition, reduced inflammation, and promoted angiogenesis. These results underscored the potential of the GG-g-(PDMAEA-co-PAMPS) hydrogel as an effective solution for chronic wound management. © 2025 American Chemical Society.

2025

Browse

Filters

Settings

Sort By

Results per page

Search Results