BHU Institutional Repository :: Browsing by Author "Kumar, Sanjay"

Browsing by Author "Kumar, Sanjay"

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A unified 2-D model for nanowire junctionless accumulation and inversion mode MOSFET in quasi-ballistic regime
(Elsevier Ltd, 2022) Baral, Kamalaksha; Singh, Prince Kumar; Kumar, Sanjay; Singh, Ashish Kumar; Jarwal, Deepak Kumar; Jit, Satyabrata
A unified 2-D continuous potential model for cylindrical nanowire junctionless accumulation mode (JAM) MOSFET and conventional inversion mode (IM) MOSFET has been presented in this manuscript. The 2-D Poisson's equation in cylindrical coordinates is solved analytically with the help of the superposition principle and evanescent mode analysis of the Fourier-Bessel series is performed. Both free and depletion charges are considered in the 2-D Poisson's equation. The model thus derived is continuous across different operation regimes (depletion and accumulation/inversion) with respect to VGS. Further, a threshold voltage model is also derived from the potential model and an expression of drain-induced barrier lowering (DIBL) is formulated. The short channel drain current model is derived from the potential-based charge model and quasi-ballistic transport velocity model. Furthermore, models for transconductance (gm) and output conductance (gd) is also formulated from the drain current model. A 3-D TCAD tool from CogendaTM has been used to numerically verify our proposed unified analytical model. � 2022 Elsevier Ltd
Analysis of GPS-TEC and IRI model over equatorial and EIA stations during solar cycle 24
(Elsevier Ltd, 2023) Kumar Chaurasiya, Sunil; Patel, Kalpana; Kumar, Sanjay; Kumar Singh, Abhay
Total Electron Content (TEC) measurements provided by Global Positioning System (GPS) as well as the International Reference Ionosphere � 2016 model (IRI01-Corr, IRI-2001, and NeQuick) model were compared at two Indian GPS stations: equatorial station Bangalore (12.580N, 77.350 E) and equatorial ionization anomaly (EIA) station Lucknow (26.500N, 80.550 E) during the solar cycle 24 extending from 2007 to 2017. The spectral, regression and statistical analysis displays a double-hump shape with counterclockwise hysteresis within TEC. The solar flux along with the TEC showed erratic as well as sluggish trends throughout the increasing period and flat and rapid throughout the decreasing period of the solar cycle 24. The semiannual and winter anomaly is discovered to be a constant feature throughout the solar cycle. The main idea of the current study is to investigate the performance of IRI01-Corr, IRI-2001, and NeQuick TEC in contrast to GPS TEC data throughout solar cycle 24 at the Indian equatorial and EIA stations. The modeled TEC data exhibit almost complete agreement with the measurement highlighting the same trends in the solar cycle as well as semiannual and seasonal changes. However, there are clear biases between the observed and modeled TECs when local time, seasons, as well as solar activity phases are considered. The main findings of this paper are that the NeQuick model generally underestimates noon-time TEC while the IRI-2001 model overestimates the same. The error in estimating noontime TEC from the IRI model using IRI-2001 as a topside at the EIA station is higher (142 %) than that at the equatorial station (42 %). � 2023 COSPAR
Appearance of de Gennes length in force-induced transitions
(American Physical Society, 2023) Chauhan, Keerti; Mishra, Garima; Kishore, Vimal; Kumar, Sanjay
Using Langevin dynamic simulations, a simple coarse-grained model of a DNA protein construct is used to study the DNA rupture and the protein unfolding. We identify three distinct states: (i) zipped DNA and collapsed protein, (ii) unzipped DNA and stretched protein, and (iii) unzipped DNA and collapsed protein. Here, we find a phase diagram that shows these states depending on the size of the DNA handle and the protein. For a less stable protein, unfolding is solely governed by the size of the linker DNA, whereas if the protein's stability increases, complete unfolding becomes impossible because the rupture force for DNA has reached a saturation regime influenced by the de Gennes length. We show that unfolding occurs via a few intermediate states by monitoring the force-extension curve of the entire protein. We extend our study to a heterogeneous protein system, where similar intermediate states in two systems can lead to different protein unfolding paths. � 2023 American Physical Society.
Arsenic-induced responses in plants: Impacts on biochemical processes
(wiley, 2022) Kumar, Sanjay; Rani, Varsha; Singh, Simranjeet; Kapoor, Dhriti; Dhanjal, Daljeet Singh; Thakur, Ankita; Pujari, Mamta; Ramamurthy, Praveen C.; Singh, Joginder
Arsenic (As) overaccumulates into plants because of mineralization, mining activities, irrigation with contaminated groundwater, wood preservatives, herbicides, insecticides, and fertilization with solid municipal wastes. The state of arsenic (III) and (V) triggers an overproduction of reactive oxygen species like hydroxyl radical, oxide radical, and hydrogen peroxide, causing oxidative damage of various biochemicals like nucleic acids, proteins, and lipids. These ions also stimulate various enzymes like catalase, ascorbate peroxidase, glutathione reductase, superoxide dismutase, guaiacol peroxidase, and nonenzymatic components like glutathione, ascorbate, carotenoid, and A-tocopherol inside the plants and act as antioxidants. Therefore, the toxicity of arsenic is stated to negatively affect the productivity as well as the quality of plants and impact the well-being and health of animals and humans consuming it. With passing time, plants have started evolving and developing strategies to curb the toxic effect induced by arsenic via mechanisms like accumulation of compatible solutes (mannitol, glycine betaine, sugar, and proline), biosynthesis of polyphenols, compartmentalization, and metal-binding proteins. Moreover, exogenous application of nitric oxide (NO), phosphate, proline, and potassium has been reported to reduce arsenic toxicity substantially. In this chapter, we explored the effects of arsenic on biochemical processes, oxidative stress, carbohydrate metabolism, lipid metabolism, and protein metabolism in arsenic-induced plants. We also discussed some directions to uncover the precise molecular mechanism involved in ameliorating arsenic-induced toxicity responses in different plants. � 2023 John Wiley & Sons, Inc.
Butylated hydroxytoluene and Butylated hydroxyanisole induced cyto-genotoxicity in root cells of Allium cepa L.
(Elsevier Ltd, 2021) Pandey, Himadri; Kumar, Sanjay
This study aims to evaluate the effects of preservatives on somatic cells of Allium cepa. For the evaluation of cytotoxicity, root meristems of A. cepa were treated with 1000, 1500, 2000, 2500 ppm concentration for 5, 10, 15 days. The root tips showed concentration dependent growth retardation in all the used concentrations, as well as root texture, also has been changed mitotic index, total protein content decreased and frequency of chromosomal aberrations increased after 5 days treatment. Additionally, the RAPD-PCR method was applied to evaluate genotoxicity and found the highest concentration (2500 ppm) was comparatively more distant to the control group. Results concluded that BHT and BHA showed positive results and cytotoxic. � 2021
Can one detect intermediate denaturation states of DNA sequences by following the equilibrium open-close dynamic fluctuations of a single base pair?
(American Institute of Physics Inc., 2022) Chauhan, Keerti; Singh, Amit Raj; Kumar, Sanjay; Granek, Rony
Melting of DNA sequences may occur through a few major intermediate states, whose influence on the melting curve has been discussed previously, while their effect on the kinetics has not been explored thoroughly. Here, we chose a simple DNA sequence, forming a hairpin in its native (zipped) state, and study it using molecular dynamic (MD) simulations and a model integrating the Gaussian network model with bond-binding energies - the Gaussian binding energy (GBE) model. We find two major partial denaturation states, a bubble state and a partial unzipping state. We demonstrate the influence of these two states on the closing-opening base pair dynamics, as probed by a tagged bond auto-correlation function (ACF). We argue that the latter is measured by fluorescence correlation spectroscopy experiments, in which one base of the pair is linked to a fluorescent dye, while the complementary base is linked to a quencher, similar to the experiment reported by Altan-Bonnet et al. [Phys. Rev. Lett. 90, 138101 (2003)]. We find that tagging certain base pairs at temperatures around the melting temperature results in a multi-step relaxation of the ACF, while tagging other base pairs leads to an effectively single-step relaxation, albeit non-exponential. Only the latter type of relaxation has been observed experimentally, and we suggest which of the other base pairs should be tagged in order to observe multi-step relaxation. We demonstrate that this behavior can be observed with other sequences and argue that the GBE can reliably predict these dynamics for very long sequences, where MD simulations might be limited. � 2022 Author(s).
Chloroplast derived SSRs reveals genetic relationships in domesticated alliums and wild relatives
(Springer Science and Business Media B.V., 2022) Jayaswall, Kuldip; Sharma, Himanshu; Bhandawat, Abhishek; Sagar, R.; Jayaswal, Deepanshu; Kumar, Akash; Chaturvedi, Pratibha; Mahajan, Vijay; Kumar, Sanjay; Singh, Major
Alliums comprise of popular spices and used for various culinary purposes and nutraceuticals. Poor genetic characterization and scarce information regarding domestication, evolution of important alliums like onion, garlic and wild relatives are the major bottleneck to alliums improvement programs. In present study, chloroplast simple sequence repeat (cpSSR) markers were developed from Allium paradoxum plastome to examine the genetic relationships among onion, garlic and wild germplasms. A total of 15 cpSSR markers were used to establish genetic relationships in 18 individuals of alliums, producing 40 alleles ranging from 1 to 6 alleles per SSR locus and polymorphism potential of 100%.Average PIC and heterozygosities was found to be 0.392 and 0.330, respectively. The developed cpSSR significantly assisted the phylogenetic study and evolutionary relationships among various Allium species. In future, these cpSSR markers will be useful for varietal identification, purity testing and genetic improvement of alliums. � 2021, The Author(s), under exclusive licence to Springer Nature B.V.
Cobalt (III) complex exerts anti-cancer effects on T cell lymphoma through induction of cell cycle arrest and promotion of apoptosis
(Springer Science and Business Media Deutschland GmbH, 2022) Verma, Praveen Kumar; Singh, Rishi Kant; Kumar, Sandeep; Shukla, Alok; Kumar, Sanjay; Gond, Mannu Kumar; Bharty, Manoj Kumar; Acharya, Arbind
Purpose: Cobalt-based compounds are emerging as a non-platinum-based anti-cancer effective therapeutic agent. However, there is a limited study regarding the therapeutic efficacy of Cobalt-based drugs against Non-Hodgkin�s Lymphoma (NHLs) such as T cell lymphoma. Therefore, in the present study we investigated the anti-tumor role of cobalt(III) complex [Co(ptsm)NH3(o-phen)]�CH3OH on Dalton�s Lymphoma (DL) cells. Materials and methods: Cytotoxicity of the cobalt complex was estimated by MTT assay. Analysis of mitochondrial membrane potential, cell cycle and Reactive oxygen species (ROS) generation, and Annexin V/PI staining was done by Flow cytometry, while AO/EtBr staining by fluorescence microscopy in cobalt complex treated DL cell. Expression of cell cycle and apoptosis regulatory protein was analyzed by Western blotting. In addition, in vivo study of the cobalt complex was evaluated in well-established DL bearing mice by monitoring physiological parameters and mean survival time. Results: Our study showed that cobalt complex triggered apoptosis and induced cell cycle arrest in DL cells. Furthermore, this also decreased mitochondrial membrane potential and increased intracellular ROS generation in cancer cells. In addition, changed expression of cell cycle and apoptosis regulatory protein was found with enhanced activity of caspase-3 and 9 in the treated cells. Additionally, administration of cobalt complex showed a significant increase in the survivability of tumor-bearing host, which was accomplished by decreasing physiological parameters. Conclusion: Taken together, these data revealed anti-tumor potential of cobalt complex against DL cells through cell cycle arrest and mitochondrial-dependent apoptosis. Henceforth, cobalt-based drugs could be a new generation therapeutic drug to treat hematological malignancies. Graphical abstract: [Figure not available: see fulltext.]. � 2022, Springer Nature Switzerland AG.
Correction to: Ganga river water quality assessment using combined approaches: physico-chemical parameters and cyanobacterial toxicity detection with special reference to microcystins and molecular characterization of microcystin synthetase (mcy) genes carrying cyanobacteria (Environmental Science and Pollution Research, (2022), 29, 9, (13122-13140), 10.1007/s11356-021-16589-1)
(Springer Science and Business Media Deutschland GmbH, 2022) Kesari, Vigya; Kumar, Sanjay; Yadav, Indrajeet; Chatterjee, Antra; Rai, Shweta; Pandey, Shraddha
The last digit of third gene sequence number is needed to be change to 6 instead of 4. Gene bank accession ID numbers are MZ222414, MZ222415, and MZ222416 for mcyE, mcyA, and mcyB genes, respectively. � 2021, Springer-Verlag GmbH Germany, part of Springer Nature.
Critical behavior of magnetic polymers on the three-dimensional Sierpi?ski Gasket
(American Physical Society, 2023) Rudra, Sumitra; Foster, Damien Paul; Kumar, Sanjay
We present the (numerically) exact phase diagram of a magnetic polymer on the Sierpi?sky gasket embedded in three dimensions using the renormalization group method. We report distinct phases of the magnetic polymer, including paramagnetic swollen, ferromagnetic swollen, paramagnetic collapsed, and ferromagnetic collapsed states. By evaluating critical exponents associated with phase transitions, we located the phase boundaries between different phases. If the model is extended to include a four-site interaction which disfavors configurations with a single spin of a given type, we find a rich variety of critical behaviors. Notably, we uncovered a phenomenon of reentrance, where the system transitions from a collapsed (paramagnetic) state to a swollen (paramagnetic) state followed by another collapse (paramagnetic) and ultimately reaching a ferromagnetic collapsed state. These findings shed new light on the complex behavior of (lattice) magnetic polymers. � 2023 American Physical Society.
Design, synthesis and in-silico & in vitro enzymatic inhibition assays of pyrazole-chalcone derivatives as dual inhibitors of ?-amylase & DPP-4 enzyme
(Springer Science and Business Media Deutschland GmbH, 2022) Nidhar, Manisha; Sonker, Priyanka; Sharma, Vishal Prasad; Kumar, Sanjay; Tewari, Ashish Kumar
A series of pyrazole-chalcone derivatives were designed, synthesized and evaluated for their in vitro ?-amylase & DPP-4 inhibitory activity. The structure of the compounds thus prepared was confirmed by analytical, and spectral techniques, 1H-NMR, 13C-NMR and Mass spectroscopy. To preliminarily investigate the molecular targets and to confirm the experimental activity testing for these anti-diabetic compounds, the molecular docking studies were determined, using different target receptors i.e., DPP-4 (PDB: 2OLE), PPAR? (PDB: 5Y2O) & ?-amylase enzyme (PDB: 5E0F). The docking study results revealed that pyrazole-chalcone derivatives exhibited better binding interaction to ?-amylase enzyme over the DPP-4 enzyme & PPAR?. Depending on in silico experiments the designed compounds were selectively prioritized for synthesis. The synthesized compounds were subjected to enzyme-based in vitro ?-amylase, DPP-4 inhibitory, and antioxidant activity. ADMET parameters like HBD, HBA, PSA, cLogP, molecular weight, bioavailability, and drug-likeness further confirmed that the compounds are potential lead compounds for future study. Compounds 4d and 6a exhibited highest activity toward ?-amylase enzyme and DPP-4 enzyme. � 2021, Institute of Chemistry, Slovak Academy of Sciences.
Development of chloroplast derived SSR markers for genus Allium and their characterization in the allies for genetic improvement of Alliums
(Elsevier B.V., 2023) Jayaswall, Kuldip; Sharma, Himanshu; Jayaswal, Deepanshu; Sagar, R.; Bhandawat, Abhishek; Kumar, Akash; Sharma, Isha; Chaturvedi, Pratibha; Manjunathagowda, Dalasanuru Chandregowda; Kumar, Deepesh; Mahajan, Vijay; Kumar, Sanjay; Singh, Major
Alliums are the most popular for their culinary usage and nutraceutical benefits. Their production is greatly affected by the multiple biotic and abiotic stresses. Poor characterizations of genetic resources are the major bottleneck in the genetic improvement of Alliums. Chloroplast-derived simple sequence repeat has recently gained much popularity due to their maternal inheritance and low recombination along with their hypervariable nature. In this study, 22 of the 28 chloroplast-derived markers from chloroplast genomes of A. cepa and A. sativum were reported as polymorphic and cross-transferable. Tetra nucleotide repeats were more prevalent (52 %) in these 22 cpSSR markers as compared to other repeat motifs. Further polymorphic information content of these 22cpSSR markers ranged from 0.007 to 0.427. Based on the genotyping of 22cpSSR markers, 25 Alliums were clustered into two groups (groups I, IIA, and IIB). This showed that cultivated Allium cepa and Allium sativum belong to group II rather than the majority of wild Alliums, which belong to group I. Hence This proved the widespread use of these AccpSSR and AscpSSR markers. Additionally, it was clear from 79 Alliums morphological and genotyping-based clustering that these 79 wild Alliums exhibit strong clustering consistency in genotyping and phenotyping-based dendrograms, hence confirming these cpSSR's discrimination potential. Allium tuberosum Rottler ex. Spreng is quite distinct from Allium fistulosum L, A. schoenoprasumas as well as Allium cepa var. aggregatum G.Don. Further Allium fistulosum L, A. schoenoprasum and Allium cepa var. aggregatum are closely related, according to genotyping-based dendrograms of 79 wild Alliums. Hence Allium fistulosum L, A. schoenoprasum, and Allium cepa provide a brilliant opportunity for introgression of the high total soluble content, high quercetin content, and allicin content of cultivated Allium into wild Allium as well as the biotic and abiotic stress tolerance of wild Alliums into cultivated Alliums. Subsequent clustering of 79 Alliums further allowed us to identify diverse Alliums for constructing a core collection. Hence present study will be useful for molecular breeding and genomic selection-based crop improvement. � 2023 SAAB
Dynamics of a polymer chain translocating through varying cone-shaped channels
(American Physical Society, 2021) Chauhan, Keerti; Kumar, Sanjay
By employing the exact enumeration technique, we study consequences of different apex angles of a wedge-shaped channel on the mean first passage time and free-energy profile of a linear polymer chain translocating from the cis- to the trans-side through an interacting pore. We investigate effects of asymmetry arising in the free-energy profile due to the change in apex angles and its dependence on the first passage time. We report the combined effect of entropy (arising due to apex angles) and pore interaction on the nonmonotonic behavior of the translocation time. The effect of different solvent quality across the channel has also been explored. We show that the increase in monomer-monomer interaction leads to the formation of globules near the pore, which drives the process faster. � 2021 American Physical Society.
Effect of 21 June 2020 solar eclipse on the ionosphere using VLF and GPS observations and modeling
(Elsevier Ltd, 2022) Tripathi, Gaurish; Singh, S.B.; Kumar, Sanjay; Singh, Ashutosh K.; Singh, Rajesh; Singh, A.K.
A solar eclipse event provides a great opportunity to examine the behavioral concept of the ionospheric electron density (Ne) variability in the low latitude region. The current work presents our outcomes from the simultaneous assessment of Tweeks (radio atmospherics) and radio signals (fixed frequency of the transmitter's signal) from multifarious VLF transmitters observed at Varanasi (Geog. Lat. 25.270N, Geog. Long. 82.980 E, Geomag. Lat. 140 55?N). To find the presence of disturbances in the ionosphere Global Positioning System (GPS) data at Hyderabad (geog. lat. 170 20/ N, long. 780 30/ E) and Bangalore (geog. lat. 120 58/ N, long. 770 33/ E) is also analyzed during the period of the solar eclipse on 21 June 2020. As the Sun was eclipsed, the nighttime phenomenon of �Tweeks' was also observed in the daytime through the annular solar eclipse due to nighttime conditions as the solar disc was dusked. Tweek analysis shows the variation in the ionospheric reflection heights (?8�11 km) and electron density (?3�2 cm?3) in the D-region during the eclipse. The reflection height of the D-region ionosphere increases from ?84 km and goes to ?95 km and then decreases to ?87 km. Electron concentration (electron density) decreased throughout the eclipse from 24 cm?3 to 21 cm?3 and then increases to 23 cm?3. Eclipse-imposed modifications in VLF transmitter's (HWU and NWC) signals displays an average change (decrease) of 2.8 dB and 0.8 dB in the signal strength of 18.3 kHz (HWU) and 19.8 kHz (NWC) transmitters respectively and a rise in virtual reference height (H?) and sharpness factor (?), as compared with normal days. The de-trended value of total electron content (DTEC) variations at both stations clearly shows the presence of travelling ionospheric disturbances (TIDs) having wave-like features. The Fast Fourier Transform (FFT) analysis shows that periodicity at both the station lies in two regimes one belongs to a period between 20 and 50 min and the other belongs to 50�90 min indicating such oscillation observed in the ionosphere are induced by atmospheric gravity waves (AGWs) generated during the period of the solar eclipse. � 2021 COSPAR
Effect of intense geomagnetic storms on low-latitude TEC during the ascending phase of the solar cycle 24
(Springer, 2021) Singh, Abha; Rathore, Vishnu S.; Kumar, Sanjay; Rao, S.S.; Singh, Sudesh K.; Singh, A.K.
The results presented in this paper are obtained from low-latitude ionospheric total electron content (TEC) variation during the chosen geomagnetic storm events happening during the solar cycle 24. We include the four intense geomagnetic storms that occurred on 26 September 2011, 15 July 2012, 19 February 2014 and 20 December 2015, depending upon the availability of TEC data. For this, we have used the TEC data from low-latitude station Varanasi (geographic latitude 25�, 16?N, geographic longitude 82�, 59?E and geomagnetic latitude 16�, 24?N) and an equatorial station Bengaluru (geographic latitude 13�, 02?N, geographic longitude 77�, 34?E and geomagnetic latitude 04�, 68?N). The storm-induced TEC changes at chosen stations have been discussed in terms of local time, storm wind effect, neutral wind, composition changes and variation in the dawn�dusk component of the interplanetary electric field (IEF Ey). � 2021, Indian Academy of Sciences.
Effect of loop sequence on unzipping of short DNA hairpins
(American Physical Society, 2021) Upadhyaya, Anurag; Kumar, Sanjay
The dependence of stability on the sequence of a DNA hairpin has been investigated through atomistic simulations. For this, a sequence of 16 bases of a hairpin, which consists of a loop of four bases and a stem of six base pairs, has been considered. We have taken eight different sequences, where the first five base pairs were kept fixed in all sequences, whereas the loop sequence and the identity of the duplex base pair closing the loop have been varied. For these hairpin structures, force-induced melting (unzipping) studies were carried out to investigate the effect of the variables on the stability of hairpin. The temperature at which half of the base pairs are open is termed the melting temperature. We defined the unzipping force Fh (half of the base pairs are open) and showed that it may not provide the effect of closing the base pair or loop sequence on the stability of the DNA hairpin. In order to have a better understanding of the stability of a DNA hairpin, the closing base pair or hairpin loop must be open. This requires complete opening of the stem. We defined a force Fc at which all base pairs of the stem are open, and we showed that the Fc gives better understanding of DNA hairpin stability. � 2021 American Physical Society.
Effect of solvent gradient inside the entropic trap on polymer migration
(American Physical Society, 2022) Mohanta, Dibyajyoti; Giri, Debaprasad; Kumar, Sanjay
By employing the exact enumeration technique on the lattice model of a polymer, we study the migration of the polymer chain across an entropic trap in a quasiequilibrium condition and explore the effect of solvent gradient present in the entropic trap which acts both parallel and perpendicular to the direction of migration. The Fokker-Planck formalism utilizes the free energy landscape of a polymer chain across the channel in the presence of the entropic trap to calculate the migration time. It is revealed that the migration is fast when the solvent gradient acts along the migration axis (i.e., x axis) inside the channel in comparison to the channel having the entropic trap. We report here for the first time that the entropic trap makes the migration faster at a certain value of solvent gradient. We also study the effect of transverse solvent gradient (along the y axis) inside the trap and investigate the structural changes of the polymer during migration through the channel. We observe the nonmonotonic dependence of migration time on the solvent gradient. � 2022 American Physical Society.
Effect of solvent gradient on DNA confined in a strip
(Elsevier B.V., 2021) Mohanta, Dibyajyoti; Giri, Debaprasad; Kumar, Sanjay
We consider a double-stranded DNA (dsDNA) confined between two walls of a strip of finite width. We investigate the effect of solvent gradient on the transfer of dsDNA from one wall to the other. For this a mutually self-attracting self-avoiding walk model of polymer has been considered on the square lattice. The strength of base-pairing interactions between the two strands across the strip has been varied to model the solvent gradient. Using the exact enumeration technique we explored the effect of sequence and solvent gradient on the melting profile of short chain DNA. These results are substantiated by Monte Carlo simulations for a longer chain. The simple model presented here captures essential physics of transport in the biological processes. � 2020 Elsevier B.V.
Effect of sowing date and inter-row annual legume green-manuring on growth, yield and quality of desi cotton (Gossypium arboreum)
(Indian Society of Agronomy, 2022) Singh, Balwant; Meena, R.N.; Meena, Ashvin Kumar; Meena, Kamlesh; Akash, A.; Meena, R.; Kumar, Sanjay
A field experiment was conducted during the rainy (kharif) season of 2018 at the Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, to study the effect of sowing date and inter-row annual legume green-manuring on desi cotton (Gossypium arboreum L). The experiment comprised 5 sowing dates, viz. 20 April, 5 May, 20 May, 5 June, 20 June, in main plot and 4 inter-row legume green-manuring, viz. dhaincha [Sesbania bispinosa (Jacq.) Wight], sunnhemp (Crotalaria juncea L.), clusterbean [Cyamopsis tetragonoloba (L.) Taub.] and cowpea [Vigna unguiculata (L.) Walp.] in subplot. The results indicated that, growth parameters, yield attributes and quality parameters were found maximum in desi cotton when sown on 20 April and minimum when sown on 20 June. Amongst inter-row legume green-manuring, sunnhemp resulted in significantly maximum growth, yield and quality parameters. Thus, desi cotton sown on 20 April with inter-row legume green-manuring of sunnhemp was found better for improving the growth, yield and quality. � 2022, Indian Society of Agronomy. All rights reserved.
Evidence that PKC? inhibition in Dalton's Lymphoma cells augments cell cycle arrest and mitochondrial-dependent apoptosis
(Elsevier Ltd, 2022) Singh, Rishi Kant; Verma, Praveen Kumar; Kumar, Sandeep; Shukla, Alok; Kumar, Naveen; Kumar, Sanjay; Acharya, Arbind
Protein kinase C? (PKC?), belonging to ser/thr protein kinase, perform various biological functions. Overexpression of PKC? has been observed in multiple human malignancies including lymphoma. However, the molecular pathogenesis and involvement of PKC? in Non-Hodgkin lymphoma (NHL) are not clearly understood. Hence, deciphering the role of PKC? in NHL management may provide a better therapeutic option. In the present study, we used selective pharmacological inhibitors G�6976 and Ro320432 that potentially inhibit PKC?-mediated signaling in DL cells, resulting in the inhibition of cell growth and mitochondrial-dependent apoptosis. PKC? inhibition by these inhibitors also displays cell cycle arrest at the G1 phase and causes growth retardation of DL cells. Our results extended the mechanism of PKC? in NHL, and provided potential implications for its therapy. � 2022 Elsevier Ltd

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