Browsing by Author "Tiwari V.K."
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Item Benzotriazole ring cleavage methodology under free radical condition: an ample opportunity in organic synthesis(Elsevier, 2024) Yadav M.S.; Gupta A.; Singh A.S.; Tiwari V.K.Since long back, benzotriazoles have been used as valuable synthons in organic synthesis. Because of their distinctive structural domain, this favors denitrogenation for easy access to biologically relevant molecules through the benzotriazole ring cleavage (BtRC) methodology followed by the generation of new bonds. Recent developments in transition metal�catalyzed coupling reactions have produced a variety of functionalizations of benzotriazoles as constituents of ortho-amino arene diazonium, primarily including cyclization, arylation, alkenylation, alkylation, carbonylation, and the formation of carbon-heteroatom bonds. In this chapter, we briefly emphasize the growing impact of BtRC methodology exploited under free-radical conditions with their notable features and applications in organic synthesis. � 2024 Elsevier Inc. All rights are reserved including those for text and data mining AI training and similar technologies.Item Carbon-Based and TMDs-Based Nanostructured Anode Materials for Improved Lithium-Ion and Sodium-Ion Battery Performances(World Scientific Publishing Co., 2024) Tiwari V.K.; Singh R.K.The hierarchical designing and structural modifications of nanostructured materials for optimum battery performance have been exploited to fulfill the growing demand of high energy-storage devices. Precise synthesis methods, doping, and structural modification of active materials have shown great advantages in restricting phase transformation, volume expansion, dendritic growth, poor ionic and electronic conductivity, transition metal dissolution, etc. Nanostructured materials (e.g., carbon and transition metal dichalcogenides (TMDs)) have significant scientific and industrial importance owing to the higher surface area to volume ratio, molecular level interactions, and possible appearance of quantum effects at the nanoscale. This chapter focuses on the role of nanostructured materials as anode materials (negative electrodes) for rechargeable battery applications and assists the design of safe, high capacity, long cyclability, and high energy density cell formation with carbon and TMDs electrode materials. � 2024 World Scientific Publishing Company.Item Click Chemistry(Springer Nature, 2024) Tiwari V.K.; Jaiswal M.K.; Rajkhowa S.; Singh S.K.This book comprehensively covers the fundamentals and latest advancements in the area of click chemistry. It discusses notable applications of click chemistry in various emerging areas ranging from chemical biology to catalysis and from medicinal chemistry to material sciences. Various topics covered in this book are catalysis in regioselectivity in click chemistry, organocatalysis in triazole synthesis, Bertozzi�s Bioorthogonal Concept, photo-triggered click chemistry, SuFFEx Click, Thiol-Ene Click, MCR Click, Intramolecular Click Chemistry, synthesis of diverse triazoles and their applications, Click's Post Functionalization, etc. The book is a valuable reference for beginners, researchers and professionals interested in sustainable click concept and its diverse applications in allied fields. � The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.Item Corrigendum to: Recent Progress on Synthesis of Functionalized 1,5- disubstituted Triazoles(2024) Jaiswal M.K.; Gupta A.; Ansari F.J.; Pandey V.K.; Tiwari V.K.Two errors appeared in the text of the manuscript titled "Recent Progress on Synthesis of Functionalized 1,5- disubstituted Triazoles", 2024; 21(4) : 513-558 [1]. We regret the errors and apologize to readers. The original article can be found online at: https://www.eurekaselect.com/article/131107. Copyright� Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Item Design, synthesis, and docking study of saccharin N-triazolyl glycoconjugates(Elsevier Ltd, 2024) Bose P.; Singh M.; Gupta A.; Kumar S.; Ansari F.J.; Pandey V.K.; Singh A.S.; Tiwari V.K.To achieve better-repurposed motifs, saccharin has been merged with biocompatible sugar molecules via a 1,2,3-triazole linker, and ten novel 1,2,3-triazole-appended saccharin glycoconjugates were developed in good yield by utilizing modular CuAAC click as regioselective triazole forming tool. The docking study indicated that the resulting hybrid molecules have an overall substantial interaction with the CAXII macromolecule. Moreover, the galactose triazolyl saccharin analogue 3h has a binding energy of ?8.5 kcal/mol with 5 H-bonds, and xylosyl 1,2,3-triazolyl saccharin analogue 3d has a binding energy of ?8.2 kcal/mol with 6 H-bond interactions and have exhibited the highest binding interaction with the macromolecule system. � 2024 Elsevier LtdItem Item HFIP-Mediated Synthesis of 4-Aryl-NH-1,2,3-Triazoles and 1,5-Disubstituted 1,2,3-Triazolyl Glycoconjugates(American Chemical Society, 2024) Jaiswal M.K.; Yadav M.S.; Maurya S.; Ansari D.; Tiwari V.K.We herein report a multicomponent reaction for the synthesis of N-unsubstituted-1,2,3-triazoles and N-substituted-1,2,3 triazoles from the reaction of aldehydes, nitroalkanes, and sodium azides/glycosyl azides in the presence of 1,1,1,3,3,3-hexafluoroisopropanol, a hydrogen bond-donating reaction medium. This three-component reaction provides a metal-free strategy for sequentially forming one C-C and two C-N bonds in a one-pot fashion. One-pot mild reaction condition, operational simplicity, wide substrate scope, good functional group tolerance, easy purification, high reaction yields, and altogether excellent regioselectivity are the notable advantages of this 1,2,3-triazole-forming protocol. Moreover, this protocol provides practical access to the gram-scale synthesis of potent inhibitors of indoleamine 2,3-dioxygenase 1. � 2024 American Chemical Society.Item Multicomponent Click Reaction: An Indispensable Tool for Easy Access of Functionalized 1,2,3-Triazoles(John Wiley and Sons Inc, 2024) Yadav M.S.; Rajkhowa S.; Singh S.K.; Jaiswal M.K.; Tiwari V.K.Multicomponent reactions are operationally simple and display a significant role in diverse chemical modification by reducing reaction times as well as additional steps involved. In this review, we highlighted the impact of multi-component reactions in assistance with modular Click chemistry to develop a library of triazole-appended scaffolds including 1,2,3-triazole-fused heterocycles, glycoconjugates, macrocycles as well as in the combinatorial synthesis of differently functionalized triazoles along with mechanistic insights with a diverse range of applications in the field of medicinal chemistry. � 2024 Wiley-VCH GmbH.Item Recent Progress on Synthesis of Functionalized 1,5-disubstituted Triazoles(Bentham Science Publishers, 2024) Jaiswal M.K.; Gupta A.; Ansari F.J.; Pandey V.K.; Tiwari V.K.Immediately after the invention of �Click Chemistry� in 2002, the regioselective 1,2,3-triazole scaffolds resulted from respective organic azides and terminal alkynes under Cu(I) catalysis have been well recognized as the functional heterocyclic core at the centre of modern organic chemistry, medicinal chemistry, and material sciences. This CuAAC reaction has several notable features including excellent regioselectivity, high-to-excellent yields, easy to execute, short reaction time, modular in nature, mild condition, readily available starting materials, etc. Moreover, the resulting regioselective triazoles can serve as amide bond isosteres, a privileged functional group in drug discovery and development. More than hundreds of reviews had been devoted to the �Click Chemistry� in special reference to 1,4-disubstituted triazoles, while only little efforts were made for an opposite regioisomer i.e., 1,5-disubstituted triazole. Herein, we have presented various classical approaches for an expeditious synthesis of a wide range of biologically relevant 1,5-disubstituted 1,2,3-triazole analogues. The syntheses of such a class of diversly functionalized triazoles have emerged as a crucial investigation in the domain of chemistry and biology. This tutorial review covers the literature assessment on the development of various synthetic protocols for the functionalized 1,5-disubstituted triazoles reported during the last 12 years. � 2024 Bentham Science Publishers.Item Silicomolybdic Acid Cluster as Biocompatible Catalyst for One-Pot Tandem Synthesis of Orthogonally Protected Glycosides(American Chemical Society, 2024) Jaiswal M.K.; Yadav M.S.; Singh M.; Garai S.; Tiwari V.K.The present paper describes a new and practical approach for the one-pot preparation of O-isopropylidene derivatives and also orthogonally protected S- and O-glycosides from the corresponding unprotected saccharides by employing 2 mol % of a silicomolybdic acid (SMA) cluster as a versatile and biocompatible catalyst. The present protocol is applicable to two-step one-pot tandem transformations, which include the O-isopropylidation, spiroketal functionalization, 4,6-O-arylidene acetalations, and arylidene acetylation processes under relatively mild reaction conditions. One-pot sequential transformations, low catalyst loading, rapid transformation, high to excellent reaction yields, mild reaction conditions, and a nontoxic biocompatible workup procedure are the notable advantages of devised protocol. � 2024 American Chemical Society.Item Solvent-free Approaches towards the Synthesis of Therapeutically Important Heterocycles(Bentham Science Publishers, 2024) Priyadarshan A.; Tripathi G.; Singh A.K.; Rajkhowa S.; Kumar A.; Tiwari V.K.The development of synthetic methodologies to obtain a diverse range of heterocyclic scaffolds has been a very attractive area of research due to their vast therapeutic importance. Conventional approaches that require the use of organic solvents, which are generally flammable, toxic, and not eco-friendly, are replaced either with greener alternatives or by completely avoiding their use. In literature, several solvent-free methods have already been reported for the synthesis of vast varieties of organic compounds. This review focuses on the solvent-free methods developed for the synthesis of different types of nitrogen and oxygen heterocycles which have exhibited diverse therapeutic applications. � 2024 Bentham Science Publishers.Item Substrate-Dependent Stereoselective Synthesis of Pyrrolo[3,4-b]Pyridin-5-Ones and Pyridyl Isoindoline-1-Ones Using Bis(benzotriazol-1-yl) Ligand(John Wiley and Sons Ltd, 2024) Yadav M.S.; Jaiswal M.K.; Kumar S.; Singh S.K.; Garai S.; Tiwari V.K.The documented work highlighted the synthesis of bis(benzotriazol-1-yl) methane derivatives using silicomolybdic acid (SMA) and successfully implemented in the stereoselective synthesis of diverse pyrrolo[3,4-b]pyridin-5-one and pyridyl isoindolinones derivatives in one-pot. The pyridinamide precursor with diverse alkynes furnished Z-selectivity of pyrrolo[3,4-b]pyridin-5-one across exocyclic C=C bond while the various benzamides on treating with 2-ethynyl pyridine afforded (E)-pyridylisoindoline-1-ones as a major isomer. The single-crystal X-ray diffraction provides strong evidence in favor of the existence and orientation of developed compounds. The broad substrate scope, easy accessibility of substrates, high stereoselectivity, scale-up synthesis, and crystal evidence demonstrate the merits of the current decorum. � 2024 Wiley-VCH GmbH.Item Synthesis and Antitubercular Evaluation of Diverse Glycosylated Ureas from D-Glucose(Hindawi Limited, 2024) Tripathi N.; Tiwari V.K.N, N-disubstituted glycosylated ureas have been synthesized in good-To-excellent yields by 1,4-conjugate addition of amines to glycosylated olefinic esters followed by reaction of resulting glycosyl ?-Amino esters with diisocyanates. The developed sugar-based molecules were well characterized by extensive standard spectroscopic analysis including NMR (1H, 13C, and DEPT), IR, MS, and elemental analysis and were screened for their biological activity against Mycobacterium tuberculosis (M. Tb.), where some of them displayed potent antitubercular activity. The molecules have been designed keeping in view the well-known inhibitors of the enzymes involved in the biosynthesis of mycobacterial cell wall polymers and may be further explored as lead molecules for the successful development of a potential antitubercular drug candidate.Dedicated to Dr. Rama P. Tripathi, Former Chief Scientist at CSIR-Central Drug Research Institute, Lucknow, India, for his extraordinary contribution to "Drug development against Tuberculosis". � 2024 Neetu Tripathi and Vinod K. Tiwari.Item Thematic Issue: Emerging Aspects of Click Chemistry(Bentham Science Publishers, 2024) Tiwari V.K.; Sarma D.[No abstract available]
