Browsing by Author "Tripathi, Yamini B."

Now showing 1 - 4 of 4
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    Bronco T (Shirisadi kasaya), a polyherbal formulation prevents LPS induced septicemia in rats
    (Verduci Editore s.r.l, 2022) Mishra, P.; Pandey, R.; Tripathi, S.; Dubey, S.K.; Tripathi, Yamini B.
    OBJECTIVE: Here, Bronco T (BT), a polyherbal formulation developed in 1984 for treating asthma, has been repurposed against septicemia-induced ALI. MATERIALS AND METHODS: Lipopolysaccharides (3 mg/kg BW) were injected intraperitoneally before 24 hours of surgery to assess the cardiorespiratory parameters, blood PaO2/FiO2 and MPO, pulmonary water content and histological changes in the lungs. The pentoxifylline (PTX) (25 mg/kg BW) was used as the positive control and given one hour before LPS. BT was given 3 hours (orally at different doses of 3, 1.5 and 0.75 g/kg BW) before LPS. RESULTS: The LPS treated group showed significant bradypnea, hypotension and bradycardia, through elongated peaks (RR) and (MAP) respectively and finally death after 95 minutes of LPS injection. The PTX and BT (3 g/kg BW) pretreatment significantly prevented these changes (dose-dependent in the BT group). The survival in these groups was maintained up to 190 min after LPS. The Pentoxifylline showed a better response (75%) than Bronco T (72%). In both the treatments, a significant decrease in pulmonary water content and minimal neutrophil infiltration and intact alveoli-capillary membrane was seen in the transverse section (T.S) of the lungs. CONCLUSIONS: Significant improvement was noted in survival time with lesser tissue damage and improved pulmonary function was observed by pre-treating with Bronco T in LPS induced septicemia. � 2022 Verduci Editore s.r.l. All rights reserved.
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    Demand and Supply Gaps: Seeds and Raw Material
    (Springer International Publishing, 2022) Mishra, Priyanka; Kumar, Praveen; Tripathi, Yamini B.; Garg, Neha
    Hemp is one of the oldest known crops with huge industrial and pharmaceutical applications.Most parts of the hemp plant are used in industry: stem for fibre production, leaves for animal bedding and construction, roots in phytoremediation and flowers for essential oils and pharmaceuticals. Seeds of the Hemp plant are a rich source of various nutrients that can be used to produce oil, flour for bread supplementation, as feed for organic farming. Realizing Hemp as a multifaceted and sustainable crop, recently there is a renewed interest in Hemp production. In this chapter, we are discussing Hemp global market, demand and supply and factors affecting industrial hemp production. � The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
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    Hypoxia-Responsive Delivery Nanoplatforms in Cancer Theranostics
    (CRC Press, 2023) Mishra, Priyanka; Tripathi, Yamini B.; Dhas, Namdev L.; Garg, Neha
    Hypoxia, a key feature of the majority of widely disseminated solid tumours, is critical for angiogenesis, metastasis, and resistance to conventional cancer therapeutic methods, promoting the development of cancer. However, hypoxic cells� typical characteristics, such as a highly bio-reductive environment and low oxygen concentration, can provide stimuli-responsive drug release to aid in tumour-specific radio, chemo, sonodynamic, and photodynamic therapies. This strategy, which focuses on the habitats of inadequately oxygenated tumours, offers the potential to get around problems caused by the heterogeneous nature of tumours and may be applied to the construction of diagnostic and therapeutic nanocarriers for many solid cancer types. As a result, research into effective methods to address drug resistance in solid tumours is proceeding quickly in hypoxia-triggered nanoparticle-based drug delivery systems. The development of hypoxia-responsive nanovehicles for drug delivery to heterogeneous cancers has made considerable strides, which are presented in this chapter. The chapter�s opening sections give readers an understanding of how hypoxia develops in cancer cells as they grow and how it affects the course of the disease. Also mentioned are the existing drawbacks and potential future applications of hypoxia-stimulated nanomachines for the treatment of cancer. � 2024 selection and editorial matter, Yashwant V. Pathak, Jayvadan K. Patel, Namdev L. Dhas and Vipul P. Patel; individual chapters, the contributors.
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    Phytonutrient Inhibitors of SARS-CoV-2/NSP5-Encoded Main Protease (Mpro) Autocleavage Enzyme Critical for COVID-19 Pathogenesis
    (Taylor and Francis Ltd., 2023) Naidu, Sreus A. G.; Tripathi, Yamini B.; Shree, Priya; Clemens, Roger A.; Naidu, A. Satyanarayan
    The genomic reshuffling, mutagenicity, and high transmission rate of the SARS-CoV-2 pathogen highlights an urgent need for effective antiviral interventions for COVID-19 control. Targeting the highly conserved viral genes and/or gene-encoded viral proteins such as main proteinase (Mpro), RNA-dependent RNA polymerase (RdRp) and helicases are plausible antiviral approaches to prevent replication and propagation of the SARS-CoV-2 infection. Coronaviruses (CoVs) are prone to extensive mutagenesis; however, any genetic alteration to its highly conserved Mpro enzyme is often detrimental to the viral pathogen. Therefore, inhibitors that target the Mpro enzyme could reduce the risk of mutation-mediated drug resistance and provide effective antiviral protection. Several existing antiviral drugs and dietary bioactives are currently repurposed to treat COVID-19. Dietary bioactives from three ayurvedic medicinal herbs, 18 ?-glycyrrhetinic acid (?G = 8.86 kcal/mol), Solanocapsine (?G = 8.59 kcal/mol), and Vasicoline (?G = 7.34 kcal/mol), showed high-affinity binding to Mpro enzyme than the native N3 inhibitor (?G = 5.41 kcal/mol). Flavonoids strongly inhibited SARS-CoV-2 Mpro with comparable or higher potency than the antiviral drug, remdesivir. Several tannin hydrolysates avidly bound to the receptor-binding domain and catalytic dyad (His41 and Cys145) of SARS?CoV?2 Mpro through H-bonding forces. Quercetin binding to Mpro altered the thermostability of the viral protein through redox-based mechanism and inhibited the viral enzymatic activity. Interaction of quercetin-derivatives with the Mpro seem to be influenced by the 7-OH group and the acetoxylation of sugar moiety on the ligand molecule. Based on pharmacokinetic and ADMET profiles, several phytonutrients could serve as a promising redox nutraceutical for COVID-19 management. � 2021 Taylor & Francis Group, LLC.