2003

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https://dl.bhu.ac.in/ir/handle/123456789/88104

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Browsing 2003 by Subject "3d-metal complexes"

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    Synthesis, characterization and antitumor studies of Mn(II), Ni(II), Cu(II) and Zn(II) complexes of N-Nicotinoyl-N′-o-hydroxythiobenzhydrazide
    (2003) Shrivastav, Anuraag; Singh, Nand Kishore; Singh, Sukh Mahendra
    A new ligand N-Nicotinoyl-N′-o-hydroxythiobenzhydrazide (H2Notbh) forms complexes [Mn(Notbh)(H2O)], [M(Notbh)] [M = Ni(II) Cu(II) and Zn(II)] which were characterized by various physico-chemical techniques. All the metal complexes were observed to inhibit the growth of tumor in vitro, whereas, ligand did not. In vivo administration of these complexes resulted in prolongation of survival of tumor bearing mice. Tumor bearing mice administered with metal complexes showed reversal of tumor growth associated induction of apoptosis in lymphocytes. The paper discusses the possible mechanisms and therapeutic implication of the H2Notbh and its metal complexes in tumor regression and tumor growth associated immunosuppression.
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    Synthesis, characterization and antitumor studies of N-aroyl-N′-thioaroylhydrazines and their Co(II), Ni(II), Cu(II) and Zn(II) complexes
    (2003) Singh, Nand Kishore; Singh, Saty Brat; Singh, Nagendra; Shriviastav, Anuraag
    N-Salicyloyl-N′-p-hydroxythiobenzohydrazide (H2STPH) and N-benzoyl-N′-thiobenzohydrazide (H2BTBH) and their Co(II), Ni(II), Cu(II) and Zn(II) complexes were prepared and characterized by physicochemical studies. IR and NMR spectral studies imply dibasic tetradentate behaviour of the ligands bonding through 'thiolato' sulfur, enolic oxygen and the two hydrazinic nitrogens in a polymeric fashion. The electronic spectra indicate [Ni(STPH)(H2O)2], [Co(STPH)(H2O)2] to be distorted octahedral while [Cu(BTBH)] has a square-planar geometry. In vitro antitumor results of the ligand and the complexes on P-815 (murine mastocytoma) and L-929 (murine fibroblast) indicate that these compounds show significant inhibition of 3H-thymidine and 3H-uridine incorporation in DNA and RNA, respectively, in these tumor cells at dose levels of 1, 2.5 and 5 μg cm-3. Antitumor studies suggest that [Cu(BTBH)] has significant dose dependent inhibitory effect on DNA synthesis. In vivo administration of [Cu(BTBH)] and [Ni(STPH)(H2O)2] resulted into prolongation of life span of Dalton's Lymphoma (DL) bearing mice.