Publication: Proline-catalyzed synthesis of ?-substituted (E)-?,?-unsaturated aldehydes from epoxides
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Date
2023
Authors
Journal Title
Organic and Biomolecular Chemistry
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
A novel, simple and metal-free tandem approach for synthesizing ?-substituted (E)-?,?-unsaturated aldehyde derivatives through acid-catalyzed epoxide rearrangement and organocatalyzed aldol condensation processes has been described. This transformation has a broad substrate scope under mild conditions, including epoxides and aldehydes containing diverse functional groups, resulting in moderate to high yields of the desired products. Eventually, large-scale reactions and the synthesis of some bioactive molecules are used to demonstrate the potential applicability of the developed method. � 2023 The Royal Society of Chemistry