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Proline-catalyzed synthesis of ?-substituted (E)-?,?-unsaturated aldehydes from epoxides

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dc.contributor.authorSharma, Ajay
dc.contributor.authorPandey, Satyendra Kumar
dc.date.accessioned2025-01-28T09:30:24Z
dc.date.available2025-01-28T09:30:24Z
dc.date.issued2023
dc.description.abstractA novel, simple and metal-free tandem approach for synthesizing ?-substituted (E)-?,?-unsaturated aldehyde derivatives through acid-catalyzed epoxide rearrangement and organocatalyzed aldol condensation processes has been described. This transformation has a broad substrate scope under mild conditions, including epoxides and aldehydes containing diverse functional groups, resulting in moderate to high yields of the desired products. Eventually, large-scale reactions and the synthesis of some bioactive molecules are used to demonstrate the potential applicability of the developed method. � 2023 The Royal Society of Chemistry
dc.identifier.doihttps://doi.org/10.1039/d3ob01750h
dc.identifier.issn14770520
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/21328
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.titleProline-catalyzed synthesis of ?-substituted (E)-?,?-unsaturated aldehydes from epoxides
dc.typeArticle
dspace.entity.typePublication
journal.titleOrganic and Biomolecular Chemistry
journalvolume.identifier.volume21

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2023