Publication: Targeting of aerobic glycolysis: An emerging therapeutic approach against colon cancer
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Date
2021
Journal Title
Colon Cancer Diagnosis and Therapy
Journal ISSN
Volume Title
Publisher
Springer International Publishing
Abstract
Colon cancer is one of the leading causes of cancer-associated deaths in men as well as in women worldwide. Therefore, various researches are being conducted to identify suitable therapeutic targets for designing the safer and effective therapeutic regimens against colon cancer. In view of this, aerobic glycolysis has been identified as one of the prominent and potential therapeutic targets for the treatment of colon cancer. Interestingly, overwhelming reports suggest that not the oxidative phosphorylation (OXPHOS) but rather glycolysis is one of the major sources of energy production in colon cancer even in the presence of sufficient oxygen. Hence, the "Warburg effect" or "aerobic glycolysis" is among the most detectable features in colon cancer which directly or indirectly mediates other hallmark features. This metabolic switch benefits colon cancer in several ways with respect to its development and progression, which include promotion of macromolecular synthesis, evasion of apoptosis, drug resistance, and immunosuppression. In colon cancer, mutations in Wnt, p53, and Ras play a critical role in switching the glucose metabolism from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. Overall, targeting of aerobic glycolysis by synthetic or natural compounds may help in designing the novel therapeutic approaches for the treatment of colon cancer. � The Author(s), under exclusive license to Springer Nature Switzerland AG 2021.
Description
Keywords
Altered glucose metabolism, Glycolytic inhibitors, Metabolic switch, Phytochemicals