Publication:
Targeting of aerobic glycolysis: An emerging therapeutic approach against colon cancer

Simple item page
dc.contributor.authorJaiswara, Pradip Kumar
dc.contributor.authorGupta, Vishal Kumar
dc.contributor.authorRawat, Shiv Govind
dc.contributor.authorTiwari, Rajan Kumar
dc.contributor.authorSonker, Pratishtha
dc.contributor.authorMaurya, Rajendra Prakash
dc.contributor.authorKumar, Ajay
dc.date.accessioned2025-01-30T06:01:17Z
dc.date.available2025-01-30T06:01:17Z
dc.date.issued2021
dc.description.abstractColon cancer is one of the leading causes of cancer-associated deaths in men as well as in women worldwide. Therefore, various researches are being conducted to identify suitable therapeutic targets for designing the safer and effective therapeutic regimens against colon cancer. In view of this, aerobic glycolysis has been identified as one of the prominent and potential therapeutic targets for the treatment of colon cancer. Interestingly, overwhelming reports suggest that not the oxidative phosphorylation (OXPHOS) but rather glycolysis is one of the major sources of energy production in colon cancer even in the presence of sufficient oxygen. Hence, the "Warburg effect" or "aerobic glycolysis" is among the most detectable features in colon cancer which directly or indirectly mediates other hallmark features. This metabolic switch benefits colon cancer in several ways with respect to its development and progression, which include promotion of macromolecular synthesis, evasion of apoptosis, drug resistance, and immunosuppression. In colon cancer, mutations in Wnt, p53, and Ras play a critical role in switching the glucose metabolism from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. Overall, targeting of aerobic glycolysis by synthetic or natural compounds may help in designing the novel therapeutic approaches for the treatment of colon cancer. � The Author(s), under exclusive license to Springer Nature Switzerland AG 2021.
dc.identifier.doihttps://doi.org/10.1007/978-3-030-64668-4_11
dc.identifier.isbn978-303064668-4; 978-303064667-7
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/24908
dc.publisherSpringer International Publishing
dc.subjectAltered glucose metabolism
dc.subjectGlycolytic inhibitors
dc.subjectMetabolic switch
dc.subjectPhytochemicals
dc.titleTargeting of aerobic glycolysis: An emerging therapeutic approach against colon cancer
dc.typeBook chapter
dspace.entity.typePublication
journal.titleColon Cancer Diagnosis and Therapy
journalvolume.identifier.volume2

Files

Collections

2021