Publication: Emerging role of ?? T cells in protozoan infection and their potential clinical application
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Date
2022
Journal Title
Infection, Genetics and Evolution
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Abstract
?? T cells are thymus derived heterogeneous and unconventional T- lymphocyte expressing TCR ? (V ?9) and TCR? (V?2) chain and play an important role in connecting innate and adaptive armaments of immune response. These cells can recognize wide ranges of antigens even without involvement of major histocompatibility complex and exert their biological functions by cytotoxicity or activating various types of immune cells. In recent past, ?? T cells have emerged as an important player during protozoa infection and rapidly expand after exposure with them. They have also been widely studied in vaccine induced immune response against many bacterial and protozoan infections with improved clinical outcome. In this review, we will discuss the various roles of ?? T cells in immunity against malaria and leishmaniasis, the two important protozoan diseases causing significant mortality and morbidity throughout the world. � 2022
Description
Keywords
Immune response, Leishmaniasis, Malaria, Protozoan, ?? T cells