Allylthiourea-mediated self-healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release

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dc.contributor.authorYadav P.
dc.contributor.authorAfgan S.
dc.contributor.authorPal K.
dc.contributor.authorJaiswal S.
dc.contributor.authorGoswami P.
dc.contributor.authorPrakash R.
dc.contributor.authorKumar R.
dc.contributor.authorKoch B.
dc.contributor.authorMaiti P.
dc.date.accessioned2025-01-13T07:04:51Z
dc.date.available2025-01-13T07:04:51Z
dc.date.issued2024
dc.description.abstractHydrogel-based materials represent promising candidates for drug delivery. In our research, we synthesized a series of hydrogels�PVATU-1 (2:1), PVATU-2 (1:1), and PVATU-3 (0.5:1)�by adjusting the poly(vinyl alcohol) (PVA) ratio while maintaining a constant ratio of allylthiourea (ATU) monomer and glutaraldehyde cross-linker, aiming to understand their impacts on gelation. These PVATU hydrogels displayed impressive swelling in neutral conditions and exhibited visible self-healing capabilities. Notably, PVATU-1 shows superior mechanical strength among the variants. Surface analysis using AFM and SEM unveiled porous structures within the hydrogels, while thermal stability tests indicated their resilience up to 200�C. DSC analysis revealed minimal variation in glass transition temperatures (Tg), affirming stability. A distinct endothermic peak around 250�350�C across all hydrogels confirmed their semi-crystalline nature, corroborated by powder XRD. Noteworthy, PVATU-1 demonstrated optimal loading and releasing efficiency for levofloxacin, with 74.5% loading and 82.8% releasing efficiency within 18 h. Biocompatibility assessments on HeLa cells affirmed the nontoxicity of PVATU hydrogel treatments. � 2024 Wiley Periodicals LLC.
dc.identifier.doi10.1002/pol.20240149
dc.identifier.issn26424150
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/1690
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.subjectallylthiourea
dc.subjectdrug delivery
dc.subjectmechanical property
dc.subjectself-healing
dc.titleAllylthiourea-mediated self-healing hydrogels based on poly(vinyl alcohol): Enhanced cell viability/biocompatibility and sustained drug release
dc.typeArticle
journal.titleJournal of Polymer Science
journalvolume.identifier.volume62

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