Semecarpus anacardium L.f. leaf extract exhibits activities against breast cancer and prolongs the survival of tumor-bearing mice

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dc.contributor.authorSingh R.K.
dc.contributor.authorMallik B.
dc.contributor.authorRanjan A.
dc.contributor.authorTripathi R.
dc.contributor.authorVerma S.S.
dc.contributor.authorSharma V.
dc.contributor.authorGupta S.C.
dc.contributor.authorSingh A.K.
dc.date.accessioned2025-01-13T07:09:30Z
dc.date.available2025-01-13T07:09:30Z
dc.date.issued2024
dc.description.abstractSemecarpus anacardium L.f. has been commonly used in various traditional medicines from ancient times. The nuts have been described in Ayurveda medication systems to treat numerous clinical ailments. However, isolating phytochemical constituents from nuts remain challenging and exhibits cytotoxic effects on other cells. In this study, we have standardized procedures for isolating phytochemicals from the leaf extract. The ethyl acetate leaf extract selectively affects cancer cells in a dose-dependent manner (IC50: 0.57 �g/ml in MCF-7 cells) in various cancer cell lines and induces apoptosis in cancer cells. However, the non-malignant cells were relatively insensitive to the extract. Next, the incubation of the leaf extract induces cell cycle arrest and suppresses cancer cell migration in the cell culture model. Moreover, oral administration of extract significantly restored tumor growth in mice. Together, these observations suggest the anti-cancer activities of S. anacardium L.f. leaf potential for both in vitro and in vivo models. � 2023 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.doi10.1080/14786419.2023.2208719
dc.identifier.issn14786419
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/3727
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.subjectapoptosis
dc.subjectayurveda
dc.subjectbreast cancer
dc.subjectcell migration
dc.subjectphytochemical
dc.subjectSemecarpus anacardium L.f
dc.titleSemecarpus anacardium L.f. leaf extract exhibits activities against breast cancer and prolongs the survival of tumor-bearing mice
dc.typeArticle
journal.titleNatural Product Research
journalvolume.identifier.volume38

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