Exploring the Gamma-Ray Enhanced NIR-Luminescence and Cytotoxic Potential of Lanthanide-Naphthalene Dicarboxylate based Metal�Organic Frameworks

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dc.contributor.authorRao P.A.
dc.contributor.authorPadhy H.
dc.contributor.authorBandyopadhyay K.
dc.contributor.authorRao A.V.
dc.contributor.authorGanta R.
dc.contributor.authorBevara S.
dc.contributor.authorSingh B.P.
dc.contributor.authorKundrapu B.
dc.contributor.authorSaha S.
dc.contributor.authorMalla R.
dc.contributor.authorMukkamala S.B.
dc.date.accessioned2025-01-13T07:08:50Z
dc.date.available2025-01-13T07:08:50Z
dc.date.issued2024
dc.description.abstractIn this investigation, we explore the integration of lanthanides into Metal�Organic Frameworks (MOFs) to enable Near-Infrared (NIR) emission. Specifically, we focus on Lanthanide-Naphthalene Dicarboxylate based MOFs (Ln-MOFs), incorporating elements such as Praseodymium (Pr), Samarium (Sm), Dysprosium (Dy), and Erbium (Er). The synthesis of Ln-MOFs is achieved via the hydrothermal method. The structure, morphology, thermal stability, and luminescence properties of synthesized Ln-MOFs have been evaluated through different characterization techniques. Upon photoexcitation at 350�nm, Ln-MOFs show the emission in the Visible and NIR region. Further, the luminescence intensity of Ln-MOFs enhanced by 2�3 folds in the visible region and 6�8 folds in NIR region after exposing to Gamma irradiation at 150�kGy. Cytotoxic effect on the viability of MDA-MB 231 and MDA-MB 468 Triple negative breast cancer (TNBC) cells was evaluated by MTT assay. The results revealed that among all synthesized MOFs, Pr-MOF exhibited an aggressive cytotoxic effect. Additionally, analysis of phase-contrast microscopy data indicates that Pr-MOF induces alterations in the morphology of both MDA-MB 231 and MDA-MB 468 TNBC cells when compared to untreated controls. The findings in this study reveal the utilization of Ln-MOFs for studying cytotoxicity and highlight their ability to enhance near-infrared (NIR) emission when exposed to gamma radiation. � The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
dc.identifier.doi10.1007/s10895-024-03677-x
dc.identifier.issn10530509
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/3410
dc.language.isoen
dc.publisherSpringer
dc.subjectCytotoxicity
dc.subjectGamma radiation
dc.subjectLanthanide metals
dc.subjectLuminescence
dc.subjectMetal�organic frameworks
dc.subjectNear-IR emission
dc.titleExploring the Gamma-Ray Enhanced NIR-Luminescence and Cytotoxic Potential of Lanthanide-Naphthalene Dicarboxylate based Metal�Organic Frameworks
dc.typeArticle
journal.titleJournal of Fluorescence

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