Isolation, Cytotoxicity, and In-silico Screening of Coumarins from Psoralea corylifolia Linn.

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dc.contributor.authorTripathi N.
dc.contributor.authorParmar A.
dc.contributor.authorPandey N.
dc.contributor.authorBhardwaj N.
dc.contributor.authorChakrabarty S.
dc.contributor.authorSarkar R.
dc.contributor.authorKumar H.
dc.contributor.authorJain S.K.
dc.date.accessioned2025-01-13T07:06:41Z
dc.date.available2025-01-13T07:06:41Z
dc.date.issued2024
dc.description.abstractPsoralea corylifolia (syn. Cullen corylifolium), commonly called bawachi, is a medicinal plant extensively used for skin conditions like leukoderma, vitiligo, and psoriasis. It is notably rich in valuable bioactive compounds, particularly coumarins and furanocoumarins. This study isolated fourteen coumarins from P. corylifolia which were tested for cytotoxicity using the MTT assay, with compound 10 showing good cytotoxicity against A549 cells (IC50 0.9 ?M), while compound 1, compound 2, and compound 3 displaying potential cytotoxicity against MDA-MB-231 cells (IC50 0.49 ?M, 0.56 ?M, and 0.84 ?M respectively). Additionally, the compounds? interaction with Epidermal Growth Factor Receptor (EGFR) protein, highly expressed in both cell lines, was investigated through molecular modeling studies, that aligned well with cytotoxicity results. The findings revealed the remarkable cytotoxic potential of four coumarins 1, 2, 3, and 10 against A549 and MDA-MB-231 cell lines. � 2024 Wiley-VHCA AG, Zurich, Switzerland.
dc.identifier.doi10.1002/cbdv.202301841
dc.identifier.issn16121872
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/2440
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.subjectCoumarin
dc.subjectCytotoxicity
dc.subjectMolecular Modelling
dc.subjectPsoralea corylifolia
dc.subjectSAR
dc.titleIsolation, Cytotoxicity, and In-silico Screening of Coumarins from Psoralea corylifolia Linn.
dc.typeArticle
journal.titleChemistry and Biodiversity
journalvolume.identifier.volume21

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