MHC tetramer technology: Exploring T cell biology in health and disease

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dc.contributor.authorTiwari R.
dc.contributor.authorSingh V.K.
dc.contributor.authorRajneesh
dc.contributor.authorKumar A.
dc.contributor.authorGautam V.
dc.contributor.authorKumar R.
dc.date.accessioned2025-01-13T07:08:55Z
dc.date.available2025-01-13T07:08:55Z
dc.date.issued2024
dc.description.abstractMajor histocompatibility complex (MHC) tetramers stand as formidable tools within T cell biology, facilitating the exploration and comprehension of immune responses. These artificial molecules, comprising four bound MHC molecules, typically with a specified peptide and a fluorescent label, play a pivotal role in characterizing T cell subsets, monitoring clonal expansion, and unraveling T cell dynamics during responses to infections or immunotherapies. Beyond their applications in T cell biology, MHC tetramers prove valuable in investigating a spectrum of diseases such as infectious diseases, autoimmune disorders, and cancers. Their instrumental role extends to vaccine research and development. Notably, when appropriately configured, tetramers transcend T cell biology research and find utility in exploring natural killer T cells and contributing to specific T cell clonal deletions. � 2024
dc.identifier.doi10.1016/bs.apcsb.2024.02.002
dc.identifier.isbn978-044319350-7
dc.identifier.issn18761623
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/3459
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectClonal expansion
dc.subjectImmune response
dc.subjectMajor histocompatibility complex
dc.subjectTetramer
dc.subjectVaccine research
dc.titleMHC tetramer technology: Exploring T cell biology in health and disease
dc.typeArticle
journal.titleAdvances in Protein Chemistry and Structural Biology
journalvolume.identifier.volume140

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