LiBr-Promoted Reaction of ?-Ketodithioesters and Thioamides with Sulfoxonium Ylides to Synthesize Functionalized Thiophenes

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dc.contributor.authorRay S.
dc.contributor.authorGupta N.
dc.contributor.authorSingh M.S.
dc.date.accessioned2025-01-13T07:07:50Z
dc.date.available2025-01-13T07:07:50Z
dc.date.issued2024
dc.description.abstractAn operationally simple and highly efficient synthesis of functionalized thiophenes has been developed by LiBr promoted heteroannulation of ?-ketodithioesters and thioamides with bench-stable sulfoxonium ylides in open air for the first time. This one-pot strategy involves formal Csp3-H bond insertion/intramolecular cyclization cascade, featuring readily accessible starting materials, TM and additive-free condition, broad substrate scope, high functional group compatibility, and scalability. Moreover, the carbonyl, thiomethyl, and amino groups in the resulting thiophene provide a good handle on downstream transformations. � 2024 American Chemical Society.
dc.identifier.doi10.1021/acs.orglett.4c03680
dc.identifier.issn15237060
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/2948
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.titleLiBr-Promoted Reaction of ?-Ketodithioesters and Thioamides with Sulfoxonium Ylides to Synthesize Functionalized Thiophenes
dc.typeArticle
journal.titleOrganic Letters

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