Mangiferin from Enicostemma littorale Blume�with in silico and in�vitro anti-inflammatory potential

Simple item page
dc.contributor.authorKumar N.
dc.contributor.authorTripathi N.
dc.contributor.authorKumar S.
dc.contributor.authorKushwaha M.
dc.contributor.authorBanerjee C.
dc.contributor.authorDey S.
dc.date.accessioned2025-01-13T07:09:31Z
dc.date.available2025-01-13T07:09:31Z
dc.date.issued2024
dc.description.abstractThe bioassay-guided fractionation of the extract of aerial parts of Enicostemma littorale resulted in two fractions 3 and 4 with moderate and potent antioxidant activity, respectively. The purification of fraction 3 gave swertiamarin (1), while the LCMS profile of fraction 4 unveiled the presence of another constituent along with swertiamarin. The extensive purification of fraction 4 led to the unusual isolation of mangiferin (2) from E. littorale. The uncommon isolation of mangiferin from E. littorale motivated us to conduct its in silico and in�vitro screening as an anti-inflammatory agent. Both studies have proved mangiferin to be a promising anti-inflammatory molecule with a binding energy of ?9.17 kcal/mol against Cyclooxygenase-2 protein and IC50 of 146.07 nanomolar. This study is the first report of the isolation of mangiferin, a xanthone glycoside from E. littorale. Communicated by Ramaswamy H. Sarma. � 2023 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.doi10.1080/07391102.2023.2253914
dc.identifier.issn7391102
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/3738
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.subjectAnti-inflammatory
dc.subjectCOX
dc.subjectEnicostemma littorale
dc.subjectmangiferin
dc.subjectswertiamarin
dc.titleMangiferin from Enicostemma littorale Blume�with in silico and in�vitro anti-inflammatory potential
dc.typeArticle
journal.titleJournal of Biomolecular Structure and Dynamics
journalvolume.identifier.volume42

Files

Collections

2024