Congenital adrenal hyperplasia complicated by gonadotropin-dependent precocious puberty

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dc.contributor.authorAlam A.
dc.contributor.authorAgrawal N.K.
dc.contributor.authorSingh S.K.
dc.date.accessioned2025-01-13T07:06:18Z
dc.date.available2025-01-13T07:06:18Z
dc.date.issued2024
dc.description.abstractPrecocious puberty, characterised by the early appearance of secondary sexual characteristics, poses challenges in diagnosis and management. Here, we describe a case of precocious puberty diagnosed in a boy in middle childhood, who presented with progressive phallus enlargement, pubic hair development and increased aggressive behaviour. Hormonal evaluation confirmed the diagnosis of congenital adrenal hyperplasia (CAH), complicated by gonadotropin-dependent precocious puberty. The case highlights the importance of assessment of testicular volume in a patient presenting with precocious puberty. Symmetrical testicular enlargement in a patient with CAH suggests premature activation of the hypothalamic-pituitary-gonadal axis. The patient received glucocorticoid therapy to suppress androgen production related to CAH and gonadotropin-releasing hormone analogue therapy to control premature activation of the hypothalamic-pituitary-gonadal axis. Follow-up visits showed regression of secondary sexual characteristics and improved growth velocity. � BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.
dc.identifier.doi10.1136/bcr-2023-257579
dc.identifier.issn1757790X
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/2270
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.subjectDrugs: endocrine system
dc.subjectPituitary disorders
dc.titleCongenital adrenal hyperplasia complicated by gonadotropin-dependent precocious puberty
dc.typeArticle
journal.titleBMJ Case Reports
journalvolume.identifier.volume17

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