Substrate-Dependent Stereoselective Synthesis of Pyrrolo[3,4-b]Pyridin-5-Ones and Pyridyl Isoindoline-1-Ones Using Bis(benzotriazol-1-yl) Ligand

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dc.contributor.authorYadav M.S.
dc.contributor.authorJaiswal M.K.
dc.contributor.authorKumar S.
dc.contributor.authorSingh S.K.
dc.contributor.authorGarai S.
dc.contributor.authorTiwari V.K.
dc.date.accessioned2025-01-13T07:07:20Z
dc.date.available2025-01-13T07:07:20Z
dc.date.issued2024
dc.description.abstractThe documented work highlighted the synthesis of bis(benzotriazol-1-yl) methane derivatives using silicomolybdic acid (SMA) and successfully implemented in the stereoselective synthesis of diverse pyrrolo[3,4-b]pyridin-5-one and pyridyl isoindolinones derivatives in one-pot. The pyridinamide precursor with diverse alkynes furnished Z-selectivity of pyrrolo[3,4-b]pyridin-5-one across exocyclic C=C bond while the various benzamides on treating with 2-ethynyl pyridine afforded (E)-pyridylisoindoline-1-ones as a major isomer. The single-crystal X-ray diffraction provides strong evidence in favor of the existence and orientation of developed compounds. The broad substrate scope, easy accessibility of substrates, high stereoselectivity, scale-up synthesis, and crystal evidence demonstrate the merits of the current decorum. � 2024 Wiley-VCH GmbH.
dc.identifier.doi10.1002/asia.202401301
dc.identifier.issn18614728
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/2695
dc.language.isoen
dc.publisherJohn Wiley and Sons Ltd
dc.subjectBenzotriazole
dc.subjectBis(benzotriazol-1-yl) ligand
dc.subjectCyclization
dc.subjectDomino synthesis
dc.subjectFused heterocycle
dc.subjectSilicomolybdic acid
dc.subjectStereoselectivity
dc.titleSubstrate-Dependent Stereoselective Synthesis of Pyrrolo[3,4-b]Pyridin-5-Ones and Pyridyl Isoindoline-1-Ones Using Bis(benzotriazol-1-yl) Ligand
dc.typeArticle
journal.titleChemistry - An Asian Journal

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