Platelet functions in lymphatic filariasis patients

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dc.contributor.authorSurtani S.
dc.contributor.authorKailashiya J.
dc.contributor.authorAnsari M.A.
dc.contributor.authorDash D.
dc.contributor.authorYadav A.K.
dc.contributor.authorKumar A.
dc.date.accessioned2025-01-13T07:06:33Z
dc.date.available2025-01-13T07:06:33Z
dc.date.issued2024
dc.description.abstractFilariasis is a chronic disease where parasitic worms survive in human hosts even for decades and lead to complications like lymphedema and elephantiasis. Despite the persistent existence of filarial parasites in human hosts, fatal and thrombotic complications are not known, unlike other parasitic diseases like malaria. This suggests that filarial parasites might be affecting the host's platelet functions. This study was conducted to examine platelet functions in confirmed filariasis patients and healthy controls. Results showed that filariasis patients had larger platelets, inhibited aggregation, and slower speed of aggregation, compared to controls. However, in vivo markers of platelet activation and degranulation (beta thromboglobulin and soluble P-selectin) were not affected. Observations suggested that there is increased platelet turnover, cellular apoptosis and inhibited platelet functions in filariasis patients compared to controls. Platelet function inhibition was not associated with the duration of disease, lymphedema-affected organs, or gender of patients. This study confirms that filarial parasites modulate platelet functions in human hosts. � 2023 Elsevier Inc.
dc.identifier.doi10.1016/j.mvr.2023.104642
dc.identifier.issn262862
dc.identifier.urihttps://dl.bhu.ac.in/ir/handle/123456789/2383
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subjectBlood parasite
dc.subjectImmune modulation
dc.subjectLymphedema
dc.subjectPlatelet aggregation
dc.subjectPlatelet immune functions
dc.titlePlatelet functions in lymphatic filariasis patients
dc.typeArticle
journal.titleMicrovascular Research
journalvolume.identifier.volume152

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