Base-Induced Annulation of Glycal-Derived ?-iodopyranone with 2-Aminopyrimidinones: Access to Chiral Imidazopyrimidinones
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Date
2024
Authors
Journal Title
European Journal of Organic Chemistry
Journal ISSN
Volume Title
Publisher
John Wiley and Sons Inc
Abstract
A simple, environmentally benign and catalyst-free method for the synthesis of chirally enriched imidazo[1,2-a]pyrimidinone glycohybrids has been successfully developed. The protocol is based on a base-induced annulation of ?-iodo-pyranone with Michael addition of 2-aminopyrimidinones followed by intramolecular nucleophilic substitution reaction. The privilege of this method includes mild reaction conditions, eco-friendly solvent and a transition-metal-free approach. Moreover, using straightforward simple methods, this reaction method exhibits a broad range of substrate scope and remarkable tolerance toward various functional groups. � 2024 Wiley-VCH GmbH.
Description
Keywords
2-aminopyrimidinone, annulation reactions, glycohybrids, imidazo-pyrimidinones, Michael addition