Browsing by Author "S.N. Pandeya"

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Analgesic activity and hypnosis potentiation effect of (±)-3-menthone semicarbazone and thiosemicarbazone derivatives
(Croatian Pharmaceutical Society, 2001) V. Mishra; S.N. Pandeya
A series of (±)-3-menthone semicarbazone and thiosemi-carbazone derivatives (3a-j) were synthesised and screened for analgesic and hypnotic activities. Almost all compounds exhibited analgesic activity and (±)-3-menthone semicarbazone (3a) was found to be the most potent. In the hypnotic test, compound 3c showed a pentobarbitone-like effect.
Analgesic and hypnosis potentiation effect of some 1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-aryl guanidines.
(1992) N. Siddiqui; S.N. Pandeya
1-(2-benzothiazolyl)-1-aryl-3-phenyl-4-arylguanidines (I-X) were prepared by oxidation of 1,3-diarylthioureas. The compounds were screened for their analgesic and hypnotic activities in rats. Of these, p-methyl group substituted compound of the series was the most potent analgesic as compared to other compounds of the series. In hypnotic test all the compounds potentiated pentobarbitone-induced hypnosis.
Anticonvulsant activity of semicarbazone derivatives of Mannich bases
(2003) S.N. Pandeya; V. Sowmyalakshmi; S.S. Panda; A. Pandeya; J.P. Stables
A series of semicarbazones of semicarbazide/p-chlorophenyl semicarbazide and Mannich bases of acetophenone/p-chloroacetophenone has been synthesized and their anticonvulsant activity screened against MES and scPTZ test. p-Chlorophenyl semi-carbazone of N,N-dimethylaminopropiophenone has been found to be the most active in all these tests.
Biological activity of mannich bases
(2003) S.N. Pandeya; V.S. Lakshmi; A. Pandey
Mannich reaction involves condensation of a carbonyl compound with formaldehyde and a secondary amine. It is a mild procedure for obtaining unsaturated ketones (usually -CO-C=CH2). Mannich bases derived from chalcones and 2-dimethyl amino ethyl benzo suberone methiodide have shown promise as anticancer agents, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[N 4(5′-chloro-3′-thiosemicarbazono-isatin-1-yl) methyl)-N-piperazinyl]-3-quinoline carboxylic acid had been found to be more active than norfloxacin.
Combinatorial chemistry: A novel method in drug discovery and its application
(2005) S.N. Pandeya; D. Thakkar
Combinatorial chemistry is a new technique developed in pharmaceutical industry, which involves synthesis of compounds in mass instead of a single compound, which are screened as a whole mixture for particular biological activity. Because of the rapid synthesis of compounds, this method saves the time and cost associated with the drug discovery. This brief review article includes combinatorial strategies, screening methods and encoding technologies and some of the applications in drug discovery.
Effect of Mannich Bases on Some Plant Pathogenic Fungi
(Czech Academy of Sciences, 1998) B.K. Sarma; J.S. Srivastava; B. Prithiviraj; U.P. Singh; S.N. Pandeya
3-(2-Pyridyl)-3-iminoisatin, 1-piperidinomethyl-3-(2-pyridyl)-3-iminoisatin, and 1-acetyl-3-(2-pyridyl)-3-iminoisatin affect spore germination of Alternaria alternata, A. carthemi, Curvularia lunata, Fusarium oxysporum f.sp. ciceri and F. udum and influence the development of powdery mildew (Erysiphe pisi) on pea under glasshouse condition as well as conidial germination of E. pisi on excised pea leaves. Spore germination was inhibited in the sequence 1-acetyl-3-(2-pyridyl)-3-iminoisatin > 1-piperidinomethyl-3-(2-pyridyl)-3-iminoisatin > 3-(2-pyridyl)-3-iminoisatin followed the order accordingly. The powdery mildew development and conidial germination of E. pisi 1-piperidinomethyl-3-(2-pyridyl)-3-iminoisatin > 1-acetyl-3-(2-pyridyl)-3-iminoisatin > 3-(2-pyridyl)-3-iminoisatin. The chemicals were compared with commonly used antifungal fungicides.
Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties
(1999) S.N. Pandeya; I. Ponnilavarasan; A. Pandey; R. Lakhan; J.P. Stables
A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary amino function is not essential for anticonvulsant activity in the semicarbazone series of compounds. Presumably these compounds could further act on glycine receptors.
Evaluation of some acylamide derivatives as potential hypoglycemic agents
(1996) V. Srivastava; A.J. Suresh; S.N. Pandeya; A. Pandey
A series of new acylamide derivatives with piperidine, pyrrolidinyl and alanyl have been tested for their hypoglycemic activities. 2-(Pyrrolidinyl)-N-(3-chlorophenyl) acetamide and 2-(Piperazinyl)-N-(4-methoxy phenyl) acetamide were found to be the most active hypoglycemic compounds. Probably the amides have mode of action similar to sulphonylureas.
Mechanism of oxidation of N-aryl-N'-acylthioureas
(Chemical Publishing Co., 2011) S.N. Pandeya; Meena K. Yadav; Vaishali Mishra; Shobhit Srivastava; Bal Krishna Singh
The synthesis of N-2-(6-methoxy/6-nitrobenzothiazolyl)-N,N'-diacyl-N''-(4- methoxy/4-nitrophenyl)-guanidine (4) and 2-acetylamino-6-acetylamino-6-(methoxy/ nitro)-benzothiazoles (5) from N-aryl-N'-acetylthioureas by oxidation under various conditions is described. The structure of products was confirmed by IR and NMR spectral evidence.
Synthesis and antibacterial activities of N-benzyl isatin-3-semicarbazones and hydrazones
(Indian Drug Manufacturers' Association, 2004) S.N. Pandeya; A. Senthil Raja; G. Nath
A series of N-benzylisatin-3-semicarbazones and hydrazones has been synthesized and their antibacterial activities evaluated. For SAR studies -NH-CO- group of semicarbazones has been replaced by OCH2- moiety. The findings of this paper indicate that N-benzylisatin derivatives could be potential chemotherapeutic agents. Compound with 3-Cl substituent is more active than standard drug trimethoprim.
Synthesis and antibacterial activity of isatin-3-(isonicotinoyl) hydrazone and substituted isatin-3(Iionicotinoyl) hydrazone
(2007) S.N. Pandeya; Alka Pandey; R.L. Gupta; Kishu Tripathi
Isatin-3-(isonicotinoyl) hydrazone and substituted isatin-3(isonicotinoyl) hydrazone were synthesized and their antibacterial activity was screened. It was observed that the Mannich base with methtyl, isopropyl and isobutyl group substituted Istain-3 -(isonicotinoyl) hydrazone exhibited higher activity and inhibit the growth of almost all the tested bacteria. Among the series, the least active was the compound residues and the methyl derivative (II-20) is the most active.
Synthesis and antibacterial activity of isatin-3-semicarbazone and substituted isatin-3-semicarbazone
(2007) S.N. Pandeya; Alka Pandey; R.L. Gupta; Kishu Tripathi
Isatin-3-semicarbazone and substituted Isatin-3-semicarbozone were synthesized and their antibacterial activity was screened. It was observed that chloro (II-2), methoxy (II-6), bromo (II-4) and nitro (II-5) substituted Isatin-3-semicarbazone exhibited activity against more than 50% of bacteria. Among the series, the least active was the compound with methyl substituent (II-3) © Global Science Publications.
Synthesis and antibacterial activity of semicarbazones and thiosemicarbazones
(Chemical Publishing Co., 2007) M.K. Gupta; A.K. Sachan; S.N. Pandeya; V.S. Gangwar
Aryl semicarbazones and thiosemicarbazones have been synthesized by the condensation of aromatic carbonyl compounds with semicarbazide and thiosemicarbazide compounds respectively. The compounds have been characterized on the basis of analytical and spectral data. They have been screened for antibacterial activity by agar double dilution method. Some of them have significant activity against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa.
Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine
(1999) S.N. Pandeya; D. Sriram; G. Nath; E. De Clercq
Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4''-methyl phenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and several secondary amines. Investigation of antimicrobial activity of the compounds was made by the agar dilution method against 28 pathogenic bacteria, eight pathogenic fungi and anti-HIV activity against replication of HIV-1 (III B) in MT-4 cells. The compounds are significantly active against bacteria and fungi. Copyright (C) 1999 Elsevier Science S.A.
Synthesis and antimicrobial evaluation of some 4- or 6-chloroisatin derivatives
(2006) S.N. Pandeya; A.S. Raja; G. Nath
Two series of chloroisatin-3-semicarbazones and hydrazones have been designed and prepared by condensing 4-chloro and 6-chloroisatin with several substituted semicarbazides and related bioisosteric hydrazides, respectively. Investigation of in vitro antimicrobial activity of compounds has been performed by agar double dilution method against nine pathogenic bacteria and four pathogenic fungi. The title compounds are also screened for their antitubercular activity against Mycobacterium tuberculosis H37 Rv using microplate alamar blue assay. Many of the synthesized compounds exhibit significant antibacterial activity in comparison to sulphamethoxazole, trimethoprim and some compounds show good antifungal activity comparable to clotrimazole. The semicarbazones arised from the 6-chloroisatin series have exhibited good antimicrobial activity than that obtained from 4-chloroisatins. Compounds, 6-chloroisatin-3-(2′-chlorophenyl) semicarbazones 1b and 6-chloroisatin-3-(4′-bromophenyl) semicarbazone 4b have shown a promising activity in both antibacterial and antifungal screenings. None of the compounds has been found to be active in antitubercular screening.
Synthesis and biological activities of thiobisformamidine salts, dithiobiurets and thiobiurets
(1985) S.N. Pandeya; V. Srivastava Km.; N. Siddiqui
[No abstract available]
Synthesis and evaluation of Schiff and N-Mannich bases of isatin as potential antimicrobial agents
(2005) P.S. Bhasin; Nikhil Sachdeva; S.N. Pandeya; G. Nath; S.K. Singh
A series of schiff and N-Mannich bases of isatin (indol-2,3-dione) were designed with the aim to develop novel antimicrobial agents of synthetic origin having broad spectrum of activity and high potency. The chemical structure of all the compounds was established by means of UV, IR, 1H NMR spectra and elemental analysis(C,H,N). The compounds were then screened for in vitro antibacterial & antifungal activity against 25 pathogenic bacteria and 5 pathogenic fungi respectively. Most of the compounds showed high to moderate activity against all tested microbes.
Synthesis of N'-aryl-N3-(substituted)-α,α'-thio-bis-formamidine dihydrochlorides and their effect on blood sugar level of albino rats
(1983) S.N. Pandeya; D.P. Pathak; V. Srivastava
[No abstract available]
Synthesis of some new amidine derivatives as potent hypoglycemic agents
(1985) S.N. Pandeya; V. Srivastava
A series of S-arylformamidino-N-(alkyl/arylisothiourea) Cyclicamino dihydrochlorides were synthesised and screened for their hypoglycemic activity in normal as well as alloxanized diabetic rats. Some of the compounds (Id, Ie, Ih-1) showed more than 30% lowering of blood sugar level of Albino rats. © 1985.
Synthesis, antibacterial and antifungal activities of 2,4-diethyl-3,5- diarylimino-1,2,4-thiadiazolidines and related benzothiazolylguanidines
(1996) P.R. Naik; S.N. Pandeya; A. Pandey
A series of 2,4-diethyl-3,5-diarylimino-1,2,4-thiadiazolidines (1a-k) and 1-(benzothiazol-2-yl)-1,3-diethyl-4-aryl guanidines (2a-k) were evaluated for their antibacterial and antifungal activities. Substitution of p-ethoxy (1d) and p-chloro (1f, 2f) in the aryl ring resulted in most active compounds of the series in both activities.