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Introduction: Advanced nanomaterial based on microorganism
(Elsevier, 2025) Pooja Singh; Kshitij RB Singh; Jay Singh; Shyam S. Pandey
Nanotechnology is revolutionizing multiple disciplines by enabling the synthesis of nanomaterials with unique properties at the nanoscale. This chapter explores the microbial synthesis of nanoparticles, a green and sustainable approach that offers advantages over conventional chemical and physical methods. Microorganism-based nanomaterials are biocompatible, cost-effective, and environmentally friendly, making them suitable for applications in energy storage, environmental remediation, pharmaceuticals, agriculture, and food processing. Special emphasis is given to their role in clean energy solutions, biomedical advancements, and sustainable agricultural practices. The discussion highlights recent developments, challenges, and prospects of microorganism-derived nanomaterials for diverse industrial and scientific applications. © 2026 Elsevier Inc. All rights reserved.
Introduction: NanoBioMedicine and its promise in gastrointestinal diseases
(Elsevier, 2025) Anshu Kumar Singh; Himshikha Malviya; Vivek K. Chaturvedi; Anurag Kumar Singh; Dawesh Prakash Yadav; Jay Singh
NanoBioMedicine, an emerging interdisciplinary field, combines nanotechnology with biomedical sciences to revolutionize disease diagnosis, treatment, and prevention. This chapter delves into the promising role of NanoBioMedicine in managing gastrointestinal (GI) diseases, presenting a comprehensive overview of relevant nanotechnological fundamentals. It explores advanced drug delivery systems, such as polymeric nanoparticles, liposomes, dendrimers, and mesoporous silica nanoparticles, highlighting their synthesis methods, including nanoprecipitation, emulsion techniques, template methods, and bottom-up assembly. Nanotechnology offers significant advantages in GI disease management by enhancing drug solubility, stability, and targeted delivery, thereby improving therapeutic outcomes. However, the complex environment of the GI tract presents formidable challenges, such as enzymatic degradation and mucosal barriers, which necessitate innovative nanotechnological solutions. This chapter discusses the benefits and challenges of employing nanotechnology in gastroenterology, providing specific examples of successful applications and emphasizing the critical need to overcome physiological barriers. By addressing these challenges, NanoBioMedicine holds the potential to transform GI therapeutics, offering hope for more effective and personalized treatments. © 2026 Elsevier Inc. All rights reserved..
Nanotechnology Driven Lipid and Metalloid Based Formulations Targeting Blood–Brain Barrier (3B) for Brain Tumor
(Springer, 2025) Amulya Jindal; Mainuddin; A. Kumar; R. K. Ratnesh; Jay Singh
The evolution of nanotechnology-driven lipid and metalloid-based nanoformulations has garnered significant attention for developing effective drug delivery systems with position/time precision and efficacy. This study focuses on challenges of blood-brain barrier (BBB) and their pivotal role in drug targeting in chronic diseases such as brain tumors (BTs). These formulations encapsulate therapeutic agents within lipidic matrices, enhancing drug solubility, bioavailability, and targeted delivery. The diverse lipid materials used in these nanoformulations highlight their biocompatibility and versatility, covering a wide range of drugs. Emphasis is placed on metal nanoparticles, liposomes, ethosomes, quantum dots, carbon nanotubes, nanorobots, and micelles. The analysis explores their drug loading, stability, release characteristics, and bioavailability modulation. It also delves into the enhanced-permeability and retention (EPR) effect, crucial for passive targeting of tumors. Recent nanocarrier systems enable better penetration of therapeutic compounds through the BBB, addressing treatment failures in invasive BTs.This review highlights the latest nanotechnology developments and potential therapeutic approaches, serving as a valuable resource for researchers, clinicians, and pharmaceutical scientists. © Association of Microbiologists of India 2024.

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