Publication: Curcumin: a spice pigment against hepatic cancer
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Date
2022
Journal Title
Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma: Volume 3: Translational and Clinical Outcomes
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Hepatic cancer is one of the most deadly malignancies owing to the pivotal role of liver in physiological homeostasis. Various strategies are being implemented to combat the onset and progression of liver cancer that has achieved promising success. However, conventional therapeutic approaches have their own limitations, particularly nonspecific toxicity and the onset of the chemoresistance. Therefore alternative approaches, including bioactive components of natural origins are being explored for their antineoplastic activity. Curcumin, the yellow pigment of turmeric spice, has shown effective cytotoxic activity against numerous malignant cells, including hepatic cancer. The abilities of curcumin such as its antioxidant nature, antiinflammatory effects, immunostimulatory activity, and protective behavior against organ damage make this phytochemical as a better choice of therapeutic agent in various medical ailments including malignancies of hepatic origin. Mechanistic explorations on curcumin have identified various molecular targets for its therapeutic effects against liver cancer. Moreover, curcumin is devoid of any specific adverse effects and safe for consumption. Curcumin also exhibits chemosensitizing ability and makes liver cancer cells more susceptible to conventional chemotherapeutic drugs. Although few concerns, including bioavailability and its metabolism limit the optimal clinical exploitation of curcumin, its derivatives is found to overcome such obstacles. Collectively curcumin stands high in prospective therapeutic molecules against liver cancers with evident success in preclinical as well clinical investigations. � 2022 Elsevier Inc. All rights reserved.
Description
Keywords
analogs, chemosensitization, Curcumin, immunomodulation, liver cancer