Benzotriazole ring cleavage methodology under free radical condition: an ample opportunity in organic synthesis
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Date
2024
Authors
Journal Title
Organic Radicals
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Since long back, benzotriazoles have been used as valuable synthons in organic synthesis. Because of their distinctive structural domain, this favors denitrogenation for easy access to biologically relevant molecules through the benzotriazole ring cleavage (BtRC) methodology followed by the generation of new bonds. Recent developments in transition metal�catalyzed coupling reactions have produced a variety of functionalizations of benzotriazoles as constituents of ortho-amino arene diazonium, primarily including cyclization, arylation, alkenylation, alkylation, carbonylation, and the formation of carbon-heteroatom bonds. In this chapter, we briefly emphasize the growing impact of BtRC methodology exploited under free-radical conditions with their notable features and applications in organic synthesis. � 2024 Elsevier Inc. All rights are reserved including those for text and data mining AI training and similar technologies.
Description
Keywords
Benzotriazole ring cleavage, cyclization, free radical reaction, heterocyclic