Solid-state synthesis of novel anticancer drug eutectic mixture; anticancer, physical and thermal studies
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Date
2024
Authors
Journal Title
Materials Letters
Journal ISSN
Volume Title
Publisher
Elsevier B.V.
Abstract
Green, solvent-free synthesis is adopted for a new pharmaceutical drug-drug eutectic with the utmost 100% yield. The synthesized eutectic mixture is significant for anticancer activity. The mandate of clinical tests could be avoided as selected nicotinamide, salicylamide, p-aminoacetinilide and benzanilide are known drugs. The compositional behaviors and established phase diagrams infer the formation of eutectics. The thermal behaviors of eutectics are studied using DSC. Further studies of eutectics are targeted for their biological applications, particularly for cell viability and anticancer activity against SiHa cancer cells where eutectic of benzanilide-salicylamide system infers its potential applicability for anticancer activity. � 2024
Description
Keywords
Anticancer activity, Biomaterials, Pharmaceutical compound, Phase diagrams, Thermal analysis