Status of visfatin in female reproductive function under normal and pathological conditions: a mini review
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Date
2024
Authors
Journal Title
Molecular Biology Reports
Journal ISSN
Volume Title
Publisher
Springer Science and Business Media B.V.
Abstract
Adipokines are now well-known to regulate reproduction. Visfatin is an adipokine expressed in the hypothalamus, pituitary, ovary, uterus, and placenta of different species, and since it has been found to modulate the endocrine secretion of the hypothalamus, pituitary gland and ovary, it may be considered a novel regulator of female reproduction. Although the majority of the literature explored its role in ovarian regulation, visfatin has also been shown to regulate uterine remodeling, endometrial receptivity and embryo development, and its expression in the uterus is steroid dependent. Like other adipokines, visfatin expression and levels are deregulated in pathological conditions including polycystic ovary syndrome. Thus, the present mini-review focuses on the role of visfatin in female reproduction under both physiological and pathological conditions. � The Author(s), under exclusive licence to Springer Nature B.V. 2024.
Description
Keywords
Insulin-like growth factor-1, Reproductive processes, Spermatogenesis, Uterine function, Visfatin