MHC tetramer technology: Exploring T cell biology in health and disease
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Date
2024
Journal Title
Advances in Protein Chemistry and Structural Biology
Journal ISSN
Volume Title
Publisher
Academic Press Inc.
Abstract
Major histocompatibility complex (MHC) tetramers stand as formidable tools within T cell biology, facilitating the exploration and comprehension of immune responses. These artificial molecules, comprising four bound MHC molecules, typically with a specified peptide and a fluorescent label, play a pivotal role in characterizing T cell subsets, monitoring clonal expansion, and unraveling T cell dynamics during responses to infections or immunotherapies. Beyond their applications in T cell biology, MHC tetramers prove valuable in investigating a spectrum of diseases such as infectious diseases, autoimmune disorders, and cancers. Their instrumental role extends to vaccine research and development. Notably, when appropriately configured, tetramers transcend T cell biology research and find utility in exploring natural killer T cells and contributing to specific T cell clonal deletions. � 2024
Description
Keywords
Clonal expansion, Immune response, Major histocompatibility complex, Tetramer, Vaccine research